中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 国家新药筛选中心
G protein-coupled receptors as therapeutic targets for multiple sclerosis

文献类型：期刊论文

作者Du, Changsheng1; Xie, Xin1,2
刊名CELL RESEARCH
出版日期2012-07
卷号22期号:7页码:1108-1128
关键词G protein-coupled receptors (GPCRs) multiple sclerosis (MS) experimental autoimmune encephalomyelitis (EAE) agonist antagonist therapeutic targets
ISSN号1001-0602
DOI10.1038/cr.2012.87
文献子类Review
英文摘要G protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants. They are considered as the most successful therapeutic targets for a broad spectrum of diseases. Multiple sclerosis (MS) is an inflammatory disease that is characterized by immune-mediated demyelination and degeneration of the central nervous system (CNS). It is the leading cause of non-traumatic disability in young adults. Great progress has been made over the past few decades in understanding the pathogenesis of MS. Numerous data from animal and clinical studies indicate that many GPCRs are critically involved in various aspects of MS pathogenesis, including antigen presentation, cytokine production, T-cell differentiation, T-cell proliferation, T-cell invasion, etc. In this review, we summarize the recent findings regarding the expression or functional changes of GPCRs in MS patients or animal models, and the influences of GPCRs on disease severity upon genetic or pharmacological manipulations. Hopefully some of these findings will lead to the development of novel therapies for MS in the near future.
WOS关键词EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; CENTRAL-NERVOUS-SYSTEM ; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; BLOOD MONONUCLEAR-CELLS ; MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA ; SPHINGOSINE 1-PHOSPHATE RECEPTORS ; MONOCYTE CHEMOTACTIC PROTEIN-1 ; BETA-ENDORPHIN CONCENTRATIONS ; IMMUNOMODULATORY DRUG FTY720 ; PLATELET-ACTIVATING-FACTOR
资助项目National Natural Science Foundation of China[31000399] ; National Natural Science Foundation of China[31171348] ; National Natural Science Foundation of China[90713047] ; National Natural Science Foundation of China[31071227] ; Ministry of Science and Technology of China[2012CB910404] ; Ministry of Science and Technology of China[2008DFB30150] ; Ministry of Science and Technology of China[2009ZX09302-001]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000306004200007
出版者INST BIOCHEMISTRY & CELL BIOLOGY
源URL[http://119.78.100.183/handle/2S10ELR8/278027]  
专题国家新药筛选中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Xie, Xin
作者单位1.Tongji Univ, Lab Receptor Based BioMed, Shanghai Key Lab Signaling & Dis Res, Sch Life Sci & Technol, Shanghai 200092, Peoples R China;
2.Chinese Acad Sci, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Du, Changsheng,Xie, Xin. G protein-coupled receptors as therapeutic targets for multiple sclerosis[J]. CELL RESEARCH,2012,22(7):1108-1128.
APA Du, Changsheng,&Xie, Xin.(2012).G protein-coupled receptors as therapeutic targets for multiple sclerosis.CELL RESEARCH,22(7),1108-1128.
MLA Du, Changsheng,et al."G protein-coupled receptors as therapeutic targets for multiple sclerosis".CELL RESEARCH 22.7(2012):1108-1128.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。