中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物化学研究室
Improved synthesis of rupintrivir

文献类型：期刊论文

作者Lin DaiZong2; Qian WangKe3; Hilgenfeld, Rolf1,2; Jiang HuaLiang2; Chen KaiXian2; Liu Hong2
刊名SCIENCE CHINA-CHEMISTRY
出版日期2012-06
卷号55期号:6页码:1101-1107
关键词rupintrivir AG7088 synthesis
ISSN号1674-7291
DOI10.1007/s11426-011-4478-5
文献子类Article
英文摘要An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
WOS关键词RHINOVIRUS PROTEASE INHIBITOR ; STRUCTURE-BASED DESIGN ; BIOLOGICAL EVALUATION ; ENTEROVIRUS 71 ; INTERMEDIATE ; PROTEINASE ; EFFICIENT ; AG7088
资助项目National Natural Science Foundation of China[20872153] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[20720102040] ; National Natural Science Foundation of China[81025017] ; National Basic Research Program of China[2009CB918502] ; Chinese Academy of Sciences[XDA01040305] ; Chinese Academy of Sciences[2010T1S6] ; European Commission[HEALTH-F3-2010-260644]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000305238400032
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/278058]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Liu Hong
作者单位1.Med Univ Lubeck, Inst Biochem, Ctr Struct & Cell Biol Med, D-23538 Lubeck, Germany
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
3.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China;
推荐引用方式
GB/T 7714		 Lin DaiZong,Qian WangKe,Hilgenfeld, Rolf,et al. Improved synthesis of rupintrivir[J]. SCIENCE CHINA-CHEMISTRY,2012,55(6):1101-1107.
APA Lin DaiZong,Qian WangKe,Hilgenfeld, Rolf,Jiang HuaLiang,Chen KaiXian,&Liu Hong.(2012).Improved synthesis of rupintrivir.SCIENCE CHINA-CHEMISTRY,55(6),1101-1107.
MLA Lin DaiZong,et al."Improved synthesis of rupintrivir".SCIENCE CHINA-CHEMISTRY 55.6(2012):1101-1107.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。