Streptocarbazoles A and B, Two Novel Indolocarbazoles from the Marine-Derived Actinomycete Strain Streptomyces sp FMA
文献类型：期刊论文
| 作者 | Fu, Peng; Yang, Chunli; Wang, Yi; Liu, Peipei; Ma, Yiming; Xu, Lei; Su, Mingbo; Hong, Kui1,2,3; Zhu, Weiming |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2012-05-04 |
| 卷号 | 14期号:9页码:2422-2425 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol3008638 |
| 文献子类 | Article |
| 英文摘要 | Streptocarbazoles A (1) and B (2), two novel indolocarbazoles featuring unprecedented cyclic N-glycosidic linkages between 1,3-carbon atoms of the glycosyl moiety and two indole nitrogen atoms of the indolocarbazole core, were isolated from the marine-derived actinomycetes strain Streptomyces sp. FMA. Their structures were established by spectroscopic methods, CD spectra, and ECD quantum mechanical calculations. Compound 1 was cytotoxic on HL-60 and A-549 cell lines and could arrest the cell cycle of Hela cells at the G(2)/M phase. |
| WOS关键词 | ACTINOALLOTEICHUS-CYANOGRISEUS WH1-2216-6 ; PROTEIN-KINASE ; NATURAL-PRODUCTS ; TOPOISOMERASE-I ; STAUROSPORINE ; BIOSYNTHESIS ; DERIVATIVES ; INHIBITION ; GLUCOSE ; GROWTH |
| 资助项目 | National Basic Research Program of China[2010CB833800] ; National Natural Science Foundation of China[21172204] ; National Natural Science Foundation of China[30973680] ; National Natural Science Foundation of China[30670219] ; Major Program for Technique Development Research of New Drugs in China[2009ZX09103-046] ; Special Fund for Marine Scientific Research in the Public Interest of China[2010418022-3] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000303492200059 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278082]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Hong, Kui |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China; 3.Wuhan Univ, Sch Pharmaceut Sci, Minist Educ China, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Fu, Peng,Yang, Chunli,Wang, Yi,et al. Streptocarbazoles A and B, Two Novel Indolocarbazoles from the Marine-Derived Actinomycete Strain Streptomyces sp FMA[J]. ORGANIC LETTERS,2012,14(9):2422-2425. |
| APA | Fu, Peng.,Yang, Chunli.,Wang, Yi.,Liu, Peipei.,Ma, Yiming.,...&Zhu, Weiming.(2012).Streptocarbazoles A and B, Two Novel Indolocarbazoles from the Marine-Derived Actinomycete Strain Streptomyces sp FMA.ORGANIC LETTERS,14(9),2422-2425. |
| MLA | Fu, Peng,et al."Streptocarbazoles A and B, Two Novel Indolocarbazoles from the Marine-Derived Actinomycete Strain Streptomyces sp FMA".ORGANIC LETTERS 14.9(2012):2422-2425. |
入库方式： OAI收割
来源：上海药物研究所
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