Diastereoselective Michael reaction of chiral nickel(II) glycinate with nitroalkenes for asymmetric synthesis of beta-substituted alpha,gamma-diaminobutyric acid derivatives in water
文献类型：期刊论文
| 作者 | Wang, Jiang ; Ji, Xun; Shi, Jianmei; Sun, Haifeng; Jiang, Hualiang; Liu, Hong
|
| 刊名 | AMINO ACIDS
 |
| 出版日期 | 2012-05 |
| 卷号 | 42期号:5页码:1685-1694 |
| 关键词 | Michael reaction Nickel(II) glycinate Asymmetric synthesis Diaminobutyric acids |
| ISSN号 | 0939-4451 |
| DOI | 10.1007/s00726-011-0870-x |
| 文献子类 | Article |
| 英文摘要 | We have developed the first operationally simple and environmentally benign protocol for the aqueous asymmetric Michael addition reaction of chiral nickel(II) glycinate with nitroalkenes. The reactions proceeded smoothly in the presence of TBAB (tetrabutyl ammonium bromide) in neat water at room temperature and provided good yields of beta-substituted alpha,gamma-diaminobutyric acid derivatives with excellent diastereoselectivities. |
| WOS关键词 | ADDITION-REACTIONS ; ORGANIC-REACTIONS ; COMPLEXES ; CHEMISTRY ; CATALYSTS ; LIGANDS ; SITE |
| 资助项目 | National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; 863 Hi-Tech Program of China[2006AA020602] ; 863 Hi-Tech Program of China[2006AA10A201] ; National S&T Major Projects[2009ZX09301-001] ; National S&T Major Projects[2009ZX09501-001] ; National S&T Major Projects[2009ZX09501-010] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000302812700014 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278099]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jiang,Ji, Xun,Shi, Jianmei,et al. Diastereoselective Michael reaction of chiral nickel(II) glycinate with nitroalkenes for asymmetric synthesis of beta-substituted alpha,gamma-diaminobutyric acid derivatives in water[J]. AMINO ACIDS,2012,42(5):1685-1694. |
| APA | Wang, Jiang,Ji, Xun,Shi, Jianmei,Sun, Haifeng,Jiang, Hualiang,&Liu, Hong.(2012).Diastereoselective Michael reaction of chiral nickel(II) glycinate with nitroalkenes for asymmetric synthesis of beta-substituted alpha,gamma-diaminobutyric acid derivatives in water.AMINO ACIDS,42(5),1685-1694. |
| MLA | Wang, Jiang,et al."Diastereoselective Michael reaction of chiral nickel(II) glycinate with nitroalkenes for asymmetric synthesis of beta-substituted alpha,gamma-diaminobutyric acid derivatives in water".AMINO ACIDS 42.5(2012):1685-1694. |
入库方式： OAI收割
来源：上海药物研究所
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