Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides
文献类型：期刊论文
| 作者 | Gong Jingxu; Sheng Li; Yao Ligong; Li Jia ; Zhou Yubo; Guo Yuewei
|
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2012-03 |
| 卷号 | 32期号:3页码:593-596 |
| 关键词 | disulfides synthesis anti-tumor activity |
| ISSN号 | 0253-2786 |
| DOI | 10.6023/cjoc1101201 |
| 文献子类 | Article |
| 英文摘要 | A series of alkyl heterocyclyl disulfides were prepared by reaction of the heterocyclyl thiol with Bunte salts. All the synthesized compounds showed interesting inhibit activities toward human colon carcinoma cells (HCT-116) in vitro. The IC50 values of the tested compounds ranged from 4.8 mu g.mL(-1) to 17.7 mu g.mL(-1). |
| WOS关键词 | MANGROVE BRUGUIERA-GYMNORRHIZA ; ONE-POT SYNTHESIS ; MACROCYCLIC POLYDISULFIDE ; ANTICANCER AGENTS ; 1-CHLOROBENZOTRIAZOLE ; INHIBITORS ; ADDITIVES |
| 资助项目 | National S & T Major Project[2009ZX09301-001] ; National S & T Major Project[2009ZX09103-060] ; Natural Science Foundation of China[81072572] ; Natural Science Foundation of China[21072204] ; Natural Science Foundation of China[21021063] ; National Marine "863" Project[2011AA09070102] ; Shanghai Science and Technology Commission[09ZR1438000] ; Shanghai Science and Technology Commission[10540702900] ; Chinese Academy of Sciences[KSCX2-EW-R-15] ; Chinese Academy of Sciences[KSCX2-YW-R-18] |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4492745 |
| WOS记录号 | WOS:000302843200019 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278157]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo Yuewei |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong Jingxu,Sheng Li,Yao Ligong,et al. Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2012,32(3):593-596. |
| APA | Gong Jingxu,Sheng Li,Yao Ligong,Li Jia,Zhou Yubo,&Guo Yuewei.(2012).Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides.CHINESE JOURNAL OF ORGANIC CHEMISTRY,32(3),593-596. |
| MLA | Gong Jingxu,et al."Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides".CHINESE JOURNAL OF ORGANIC CHEMISTRY 32.3(2012):593-596. |
入库方式： OAI收割
来源：上海药物研究所
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