Terpenoids from root bark of Celastrus orbiculatus
文献类型：期刊论文
| 作者 | Wu, Jian; Zhou, Yu ; Wang, Luoyi; Zuo, Jianping; Zhao, Weimin
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2012-03 |
| 卷号 | 75页码:159-168 |
| 关键词 | Celastrus orbiculatus Celastraceae Terpenoid Celastrol T cell proliferation |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2011.11.023 |
| 文献子类 | Article |
| 英文摘要 | Phytochemical investigation of root bark of Celastrus orbiculatus afforded 10 terpenoids and eight known compounds. Their structures were established on the basis of spectroscopic and chemical methods. Celastrol and its dimers and adducts displayed moderate inhibitory activity against T cell proliferation. The reaction of celastrol under acidic conditions was undertaken, and a mechanism is presented, which may help towards modification of its structure and elucidation of the biogenetic routes to natural celastrol derivatives. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | STEREOISOMERIC TRITERPENE DIMERS ; MAYTENUS-CHUCHUHUASCA ; ABSOLUTE-CONFIGURATION ; SESQUITERPENE ESTERS ; ILICIFOLIA ; DITERPENES ; ACTIVATION ; XUXUARINES ; INHIBITORS ; WILFORDII |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09301-001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000300868600017 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278175]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Weimin |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jian,Zhou, Yu,Wang, Luoyi,et al. Terpenoids from root bark of Celastrus orbiculatus[J]. PHYTOCHEMISTRY,2012,75:159-168. |
| APA | Wu, Jian,Zhou, Yu,Wang, Luoyi,Zuo, Jianping,&Zhao, Weimin.(2012).Terpenoids from root bark of Celastrus orbiculatus.PHYTOCHEMISTRY,75,159-168. |
| MLA | Wu, Jian,et al."Terpenoids from root bark of Celastrus orbiculatus".PHYTOCHEMISTRY 75(2012):159-168. |
入库方式： OAI收割
来源：上海药物研究所
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