The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone
文献类型：期刊论文
| 作者 | Song, Shao-Xing1,2; Wu, Ming-Li1,2; He, Xiao-Peng1,2; Zhou, Yu-Bo3 ; Sheng, Li3; Li, Jia3; Chen, Guo-Rong1,2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2012-03-01 |
| 卷号 | 22期号:5页码:2030-2032 |
| 关键词 | Glycolipid Cytotoxicity Mixture MTT Glycosylation |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2012.01.069 |
| 文献子类 | Article |
| 英文摘要 | The anomeric mixture of a series of O-galactolipid derivatives is revealed to be more toxic against several cancer cell lines than their either single component with the pure alpha- or beta-configuration. This interesting phenomenon has been confirmed on pairs of synthesized O-galactosyl anomers bearing length-varied alkyl chains at the lipid end. Furthermore, the most potent mixture was determined inoffensive to a normal cell line tested. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CLICK CHEMISTRY ; GLYCOLIPIDS ; PROLIFERATION ; ASSESSMENTS ; GLYCOSIDES ; HYBRIDS ; ANALOGS ; AGENTS |
| 资助项目 | National Natural Science Foundation of China[21176076] ; National Natural Science Foundation of China[30801405] ; National Basic Research Program of China[2007CB914201] ; Shanghai Science and Technology Community[10410702700] ; Chinese Academy of Sciences[KSCX2-EW-R-15] ; China Postdoctoral Science Foundation[2011M500069] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000300451200039 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278177]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | He, Xiao-Peng |
| 作者单位 | 1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; 3.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Shao-Xing,Wu, Ming-Li,He, Xiao-Peng,et al. The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(5):2030-2032. |
| APA | Song, Shao-Xing.,Wu, Ming-Li.,He, Xiao-Peng.,Zhou, Yu-Bo.,Sheng, Li.,...&Chen, Guo-Rong.(2012).The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(5),2030-2032. |
| MLA | Song, Shao-Xing,et al."The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.5(2012):2030-2032. |
入库方式： OAI收割
来源：上海药物研究所
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