Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives
文献类型：期刊论文
| 作者 | Yao, Shuyi1; Xie, Hui2; Zhang, Li1; Meng, Tao1 ; Zhang, Yongliang1; Wang, Xin1; Chen, Lin1; Pan, Shengli2; Shen, Jingkang1
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2012-02 |
| 卷号 | 17期号:2页码:1425-1436 |
| 关键词 | laetispicine derivatives antidepressant total synthesis forced swimming test |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules17021425 |
| 文献子类 | Article |
| 英文摘要 | The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C. DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds. |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09301-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09501-010] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09103-075] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000300717200021 |
| 出版者 | MDPI AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278193]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Shen, Jingkang |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Shuyi,Xie, Hui,Zhang, Li,et al. Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives[J]. MOLECULES,2012,17(2):1425-1436. |
| APA | Yao, Shuyi.,Xie, Hui.,Zhang, Li.,Meng, Tao.,Zhang, Yongliang.,...&Shen, Jingkang.(2012).Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives.MOLECULES,17(2),1425-1436. |
| MLA | Yao, Shuyi,et al."Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives".MOLECULES 17.2(2012):1425-1436. |
入库方式： OAI收割
来源：上海药物研究所
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