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Synthesis and Immunomodulating Activity of New Analogues of Fingolimod

文献类型：期刊论文

作者Feng, Xiang-Jun1; Yang, Xiao-Ying2; Luo, Yu1; Li, Xin2; Tang, Wei2; Zuo, Jian-Ping2; Lu, Wei1,3
刊名ARCHIV DER PHARMAZIE
出版日期2012-02
卷号345期号:2页码:93-100
关键词Antigen-specific T-cell proliferation Fingolimod Immunomodulators
ISSN号0365-6233
DOI10.1002/ardp.201100092
文献子类Article
英文摘要Five new immunomodulators 1a-1e by using a trans-4-alkyl-substituted cyclohexane to replace the flexible C8 alkyl chain of Fingolimod were synthesized. For in-vitro test, the compounds were dissolved in DMSO as a stock solution and diluted to a desired concentration with RPMI 1640 nutrient solution. For in-vivo test, the compounds were prepared in pathogen-free saline containing 0.5% DMSO. These new immunomodulators displayed more potent immunoinhibitory activities in vitro and moderate immunomodulating activities in vivo. They show therapeutic effects on DNFB-induced DTH reaction and inhibitory effects on the antigen-specific T-cell proliferation.
WOS关键词SPHINGOSINE 1-PHOSPHATE ; FTY720 ; RECEPTORS ; TRANSPLANTATION ; CYCLOSPORINE ; TARGETS ; GROWTH
资助项目Lab of Organic Functional Molecules, Sino-French Institute of ECNU[00000000] ; National Science Fair Committee (NSFC)[1072652] ; National Science & Technology Major Project[2009ZX09103-070] ; National Science & Technology Major Project[2009ZX09102-019] ; National Science & Technology Major Project[2009ZX09301-001]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000299373800001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/278205]  
专题药理学第一研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Lu, Wei
作者单位1.E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China;
2.Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China;
3.E China Normal Univ, Inst Drug Discovery & Dev, Shanghai 200062, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Xiang-Jun,Yang, Xiao-Ying,Luo, Yu,et al. Synthesis and Immunomodulating Activity of New Analogues of Fingolimod[J]. ARCHIV DER PHARMAZIE,2012,345(2):93-100.
APA Feng, Xiang-Jun.,Yang, Xiao-Ying.,Luo, Yu.,Li, Xin.,Tang, Wei.,...&Lu, Wei.(2012).Synthesis and Immunomodulating Activity of New Analogues of Fingolimod.ARCHIV DER PHARMAZIE,345(2),93-100.
MLA Feng, Xiang-Jun,et al."Synthesis and Immunomodulating Activity of New Analogues of Fingolimod".ARCHIV DER PHARMAZIE 345.2(2012):93-100.

入库方式： OAI收割

来源：上海药物研究所

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