Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice
文献类型：期刊论文
| 作者 | Cao, Hui-Juan1,2; Tan, Rui-Rong1; He, Rong-Rong1,3; Tang, Lu-Ping1; Wang, Xin-Luan2; Yao, Nan1,4; Duan, Wen-Jun1; Hu, Yuan-Ao1; Yao, Xin-Sheng1; Kurihara, Hiroshi1 |
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2012 |
| ISSN号 | 1741-427X |
| DOI | 10.1155/2012/236539 |
| 文献子类 | Article |
| 英文摘要 | Sarcandra glabra, as a type of "antipyretic-detoxicate drugs", has always been widely used in traditional Chinese medicine (TCM). The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza. Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days. Body weight, morbidity, and mortality were recorded daily. Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined. Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus. However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time. The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-kappa B protein expression to ameliorate the lung injury. These data showed that SGE reduced the susceptibility and severity of influenza. |
| WOS关键词 | DIESEL EXHAUST PARTICLES ; ROSMARINIC ACID ; VIRAL-INFECTION ; A VIRUS ; EXPRESSION ; COLLECTINS ; CELLS ; RECEPTORS ; MORTALITY ; HEALTH |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1106KF-13] ; Natural Science Foundation of Guangdong Province[S2011040004893] |
| WOS研究方向 | Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000310917300001 |
| 出版者 | HINDAWI PUBLISHING CORPORATION |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278232]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | He, Rong-Rong |
| 作者单位 | 1.Jinan Univ, Dept Med, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China; 2.Chinese Acad Sci, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Translat Med Res & Dev Ctr, Shenzhen 518055, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Guangdong Prov Inst Tradit Chinese Med, Pharmacol Lab Tradit Chinese Med, Guangzhou 510095, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Hui-Juan,Tan, Rui-Rong,He, Rong-Rong,et al. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012. |
| APA | Cao, Hui-Juan.,Tan, Rui-Rong.,He, Rong-Rong.,Tang, Lu-Ping.,Wang, Xin-Luan.,...&Kurihara, Hiroshi.(2012).Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. |
| MLA | Cao, Hui-Juan,et al."Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012). |
入库方式： OAI收割
来源：上海药物研究所
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