Diketopiperazine alkaloids from a mangrove rhizosphere soil derived fungus Aspergillus effuses H1-1
文献类型：期刊论文
| 作者 | Gao, Huquan2; Liu, Weizhong2,3; Zhu, Tianjiao2; Mo, Xiaomei2; Mandi, Attila1; Kurtan, Tibor1; Li, Jing2 ; Ai, Jing4; Gu, Qianqun2; Li, Dehai2
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
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| 出版日期 | 2012 |
| 卷号 | 10期号:47页码:9501-9506 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c2ob26757h |
| 文献子类 | Article |
| 英文摘要 | Effusin A (1), a spirobicyclic N,O-acetal derivative with an unprecedented 3',3a',5',6'-tetrahydrospiro-[piperazine-2,2'-pyrano[2,3,4-de]chromene] ring system, and a spiro-polyketide-diketopiperazine hybrid dihydrocryptoechinulin D (2) were isolated from a mangrove rhizosphere soil derived fungus, Aspergillus effuses H1-1. Their structures were determined by detailed spectroscopic analysis. Effusin A (1) and dihydrocryptoechinulin D (2) occurred as racemates, the enantiomers of which were separated and characterized by online HPLC-ECD analysis and their absolute configurations were determined by the solution TDDFT ECD calculation approach. The cytotoxic effects of 1 and 2 were preliminarily evaluated and 2 showed potent activity on P388 cells with an IC50 value of 1.83 mu M. The target of racemic 2 was also investigated and the (12R,28S,31S)-2 enantiomer showed selectivity against topoisomerase I. |
| WOS关键词 | CUNNINGHAMIA-LANCEOLATA ; AMSTELODAMI ; NEOECHINULIN ; METABOLITES ; ROOTS ; ASSAY |
| 资助项目 | National Natural Science Foundation of China[41176120] ; State Key Laboratory of Drug Research[SIMM1203KF-14] ; Promotive research fund for excellent young and middle-aged scientists of Shandong Province[BS2010HZ027] ; Public Projects of State Oceanic Administration[2010418022-3] ; Program for Changjiang Scholars and Innovative Research Team in University[IRT0944] ; National Information Infrastructure Development Institute[NIIFI 10038] ; [HURO/0901/274/2.2.2] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000311161900024 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278234]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Kurtan, Tibor |
| 作者单位 | 1.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary; 2.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China; 3.Binzhou Med Coll, Dept Chem, Yantai 264003, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Huquan,Liu, Weizhong,Zhu, Tianjiao,et al. Diketopiperazine alkaloids from a mangrove rhizosphere soil derived fungus Aspergillus effuses H1-1[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2012,10(47):9501-9506. |
| APA | Gao, Huquan.,Liu, Weizhong.,Zhu, Tianjiao.,Mo, Xiaomei.,Mandi, Attila.,...&Li, Dehai.(2012).Diketopiperazine alkaloids from a mangrove rhizosphere soil derived fungus Aspergillus effuses H1-1.ORGANIC & BIOMOLECULAR CHEMISTRY,10(47),9501-9506. |
| MLA | Gao, Huquan,et al."Diketopiperazine alkaloids from a mangrove rhizosphere soil derived fungus Aspergillus effuses H1-1".ORGANIC & BIOMOLECULAR CHEMISTRY 10.47(2012):9501-9506. |
入库方式： OAI收割
来源：上海药物研究所
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