Novel Object Recognition as a Facile Behavior Test for Evaluating Drug Effects in A beta PP/PS1 Alzheimer's Disease Mouse Model
文献类型：期刊论文
| 作者 | Zhang, Ru2; Xue, Guizhen2; Wang, Shaodeng2; Zhang, Lihong2; Shi, Changjie2; Xie, Xin1,2
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| 刊名 | JOURNAL OF ALZHEIMERS DISEASE
 |
| 出版日期 | 2012 |
| 卷号 | 31期号:4页码:801-812 |
| 关键词 | A beta PP/PS1 Alzheimer's disease donepezil Morris water maze naltrindole novel object recognition |
| ISSN号 | 1387-2877 |
| DOI | 10.3233/JAD-2012-120151 |
| 文献子类 | Article |
| 英文摘要 | Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the A beta PP/PS1 transgenic mouse model is a commonly used experimental model to mimic the pathological and cognitive impairments in AD. As a classic method to evaluate spatial learning and memory, the Morris water maze is widely applied to study the cognitive deficits in rodent AD models. However, the assay procedure is relatively complicated and requires a properly equipped environment. The novel object recognition test is a relatively simple and straightforward method to test working memory in rodents. However, whether the latter can be used as a common tool for evaluating the therapeutic effects of drugs in the A beta PP/PS1 transgenic AD mouse model remains unclear. In the present study, we assessed the cognitive impairment of A beta PP/PS1 AD mice with the novel object recognition test. In parallel, Morris water maze was performed and compared with the novel object recognition study. Both assays worked equally well in evaluating the cognitive defect of A beta PP/PS1 mice. Furthermore, we drew similar conclusions from the novel object recognition assay as from the Morris water maze in assessing the therapeutic effects of two previously reported compounds, donepezil and naltrindole, on AD. We found the novel object recognition to be a facile assay with almost no stress to mice and think it could be used as an ideal primary screening assay to evaluate drug effects on A beta PP/PS1 AD model. |
| WOS关键词 | AMYLOID PRECURSOR PROTEIN ; TRANSGENIC MICE ; SYNAPTIC PLASTICITY ; RATS ; MEMORY ; TASK ; DEFICITS ; DEPOSITION ; PERFORMANCES ; PRESENILIN-1 |
| 资助项目 | Ministry of Science and Technology of China[2009ZX09302-001] ; Ministry of Science and Technology of China[2011DFB30010] ; National Natural Science Foundation of China[31071227] ; National Natural Science Foundation of China[81100963] ; National Natural Science Foundation of China[31171348] ; Shanghai Commission of Science and Technology[11DZ2292200] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000308809200013 |
| 出版者 | IOS PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278240]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xie, Xin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Tongji Univ, Sch Life Sci & Technol, Lab Receptor Based Biomed, Shanghai Key Lab Signaling & Dis Res, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ru,Xue, Guizhen,Wang, Shaodeng,et al. Novel Object Recognition as a Facile Behavior Test for Evaluating Drug Effects in A beta PP/PS1 Alzheimer's Disease Mouse Model[J]. JOURNAL OF ALZHEIMERS DISEASE,2012,31(4):801-812. |
| APA | Zhang, Ru,Xue, Guizhen,Wang, Shaodeng,Zhang, Lihong,Shi, Changjie,&Xie, Xin.(2012).Novel Object Recognition as a Facile Behavior Test for Evaluating Drug Effects in A beta PP/PS1 Alzheimer's Disease Mouse Model.JOURNAL OF ALZHEIMERS DISEASE,31(4),801-812. |
| MLA | Zhang, Ru,et al."Novel Object Recognition as a Facile Behavior Test for Evaluating Drug Effects in A beta PP/PS1 Alzheimer's Disease Mouse Model".JOURNAL OF ALZHEIMERS DISEASE 31.4(2012):801-812. |
入库方式： OAI收割
来源：上海药物研究所
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