Gold-catalyzed tandem reaction in water: an efficient and convenient synthesis of fused polycyclic indoles
文献类型：期刊论文
| 作者 | Feng, Enguang; Zhou, Yu ; Zhao, Fei; Chen, Xianjie; Zhang, Lei; Jiang, Hualiang; Liu, Hong
|
| 刊名 | GREEN CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 14期号:7页码:1888-1895 |
| ISSN号 | 1463-9262 |
| DOI | 10.1039/c2gc35293a |
| 文献子类 | Article |
| 英文摘要 | This report describes the gold-catalyzed synthesis of fused polycyclic indoles from substituted 2-(1H-indol-1-yl) alkylamines and alkynoic acids in water under microwave irradiation. This protocol proceeds in high atom economy and leads to the generation of two rings, together with the formation of one new C-C bond and two new C-N bonds in a single operation. The advantages of the method include a short reaction time, excellent yield, easy work-up, and the use of microwave irradiation and an environmentally benign solvent. |
| WOS关键词 | MICROWAVE-ASSISTED SYNTHESIS ; CHEMOTHERAPY-INDUCED NAUSEA ; ORGANIC-SYNTHESIS ; GREEN CHEMISTRY ; DRUG DISCOVERY ; EMETOGENIC CHEMOTHERAPY ; SUPERCRITICAL WATER ; DERIVATIVES ; CYCLIZATION ; DOLASETRON |
| 资助项目 | National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2012CB518000] ; National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103-101-072] ; Silver Project[260644] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000305627500011 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278256]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Feng, Enguang |
| 作者单位 | Chinese Acad Sci, Ctr Drug Discovery & Design, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Enguang,Zhou, Yu,Zhao, Fei,et al. Gold-catalyzed tandem reaction in water: an efficient and convenient synthesis of fused polycyclic indoles[J]. GREEN CHEMISTRY,2012,14(7):1888-1895. |
| APA | Feng, Enguang.,Zhou, Yu.,Zhao, Fei.,Chen, Xianjie.,Zhang, Lei.,...&Liu, Hong.(2012).Gold-catalyzed tandem reaction in water: an efficient and convenient synthesis of fused polycyclic indoles.GREEN CHEMISTRY,14(7),1888-1895. |
| MLA | Feng, Enguang,et al."Gold-catalyzed tandem reaction in water: an efficient and convenient synthesis of fused polycyclic indoles".GREEN CHEMISTRY 14.7(2012):1888-1895. |
入库方式： OAI收割
来源：上海药物研究所
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