Recent Sino-Italian collaborative studies on marine organisms from the South China Sea
文献类型：期刊论文
| 作者 | Guo, Yue-Wei2 ; Gavagnin, Margherita1; Carbone, Marianna1; Mollo, Ernesto1; Cimino, Guido1
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| 刊名 | PURE AND APPLIED CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 84期号:6页码:1391-1405 |
| 关键词 | bioactive molecules cnidarians marine chemistry molluscs natural products NMR organic chemistry polypropionates structures terpenoids |
| ISSN号 | 0033-4545 |
| DOI | 10.1351/PAC-CON-11-09-04 |
| 文献子类 | Article |
| 英文摘要 | In this communication, selected results obtained in the course of a 10-year Sino-Italian collaborative project are presented. During this collaboration, several studies on marine organisms collected in the South China Sea have been conducted, resulting in the characterization of a large number of novel natural products. The main interest has been focused on sponges, cnidarians, and molluscs. Here, the recent research, including some not yet published studies, on cnidarians and molluscs, in particular, opisthobranchs and pulmonates, will be briefly described. The study of cnidarians and pulmonates led to isolate molecules, in particular, biscembranoids and polypropionates, displaying carbon skeletons already described in previous papers. Our studies resulted in their complete structural characterization including the absolute stereochemistry that was clarified by coupling X-ray diffraction to circular dichroism (CD) spectra analysis. Some unique nitrogenous molecules containing either an isonitrile function or an 1,2,4-oxadiazole moiety, this latter found for the first time in a marine organism, as well as known sesterterpenoids and diterpenoids were isolated from opisthobranchs. Owing to their anatomical location, these metabolites should play a relevant role in the protection of the molluscs. Finally, a series of alkaloids structurally related to known anticancer agents were also characterized. |
| WOS关键词 | CORAL SARCOPHYTON-TORTUOSUM ; PROBABLE BIOGENETIC PRECURSOR ; GLOSSODORIS-ATROMARGINATA ; SPONGIAN DITERPENOIDS ; NATURAL-PRODUCTS ; NUDIBRANCH ; POTENT ; CEMBRANOLIDES ; CHROMODORIS ; OXADIAZOLES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000304210400009 |
| 出版者 | INT UNION PURE APPLIED CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278259]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Cimino, Guido |
| 作者单位 | 1.CNR, ICB, I-80078 Pozzuoli, NA, Italy; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Yue-Wei,Gavagnin, Margherita,Carbone, Marianna,et al. Recent Sino-Italian collaborative studies on marine organisms from the South China Sea[J]. PURE AND APPLIED CHEMISTRY,2012,84(6):1391-1405. |
| APA | Guo, Yue-Wei,Gavagnin, Margherita,Carbone, Marianna,Mollo, Ernesto,&Cimino, Guido.(2012).Recent Sino-Italian collaborative studies on marine organisms from the South China Sea.PURE AND APPLIED CHEMISTRY,84(6),1391-1405. |
| MLA | Guo, Yue-Wei,et al."Recent Sino-Italian collaborative studies on marine organisms from the South China Sea".PURE AND APPLIED CHEMISTRY 84.6(2012):1391-1405. |
入库方式： OAI收割
来源：上海药物研究所
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