Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues
文献类型：期刊论文
| 作者 | Cao, Bin1; Wang, Yong1; Ding, Kan1 ; Neamati, Nouri2; Long, Ya-Qiu1
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 10期号:6页码:1239-1245 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c1ob06773g |
| 文献子类 | Article |
| 英文摘要 | An efficient and easy procedure to synthesize the pyridinyl analogues of dibenzylideneacetone (pyr-dba) was developed by the condensation of substituted nicotinaldehyde and acetone in the presence of K2CO3 in toluene-EtOH-H2O solvent system. Structurally diverse pyr-dba, including quinolinyl dba, can be prepared conveniently in moderate to excellent yields under mild conditions with this method. The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-kappa B and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction. |
| WOS关键词 | ALKYLZINC REAGENTS ; OXIDATIVE ADDITION ; OLEFIN LIGAND ; KAPPA-B ; COMPLEXES ; SUBSTITUTION ; IODOBENZENE ; REACTIVITY ; NITROGEN ; KETONES |
| 资助项目 | National Natural Science Foundation of China[20872154] ; National Natural Science Foundation of China[8107257] ; National Natural Science Foundation of China[81021062] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000299342200015 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278282]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Long, Ya-Qiu |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Medica, Shanghai 201203, Peoples R China; 2.Univ So Calif, Dept Pharmacol & Pharmaceut Sci, Sch Pharm, Los Angeles, CA 90089 USA |
| 推荐引用方式 GB/T 7714 | Cao, Bin,Wang, Yong,Ding, Kan,et al. Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2012,10(6):1239-1245. |
| APA | Cao, Bin,Wang, Yong,Ding, Kan,Neamati, Nouri,&Long, Ya-Qiu.(2012).Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues.ORGANIC & BIOMOLECULAR CHEMISTRY,10(6),1239-1245. |
| MLA | Cao, Bin,et al."Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues".ORGANIC & BIOMOLECULAR CHEMISTRY 10.6(2012):1239-1245. |
入库方式： OAI收割
来源：上海药物研究所
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