Novel Rhein Analogues as Potential Anticancer Agents
文献类型：期刊论文
| 作者 | Yang, Xiaochuan1,2; Sun, Guojing1,2; Yang, Chunhao1,2,3 ; Wang, Binghe1,2
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| 刊名 | CHEMMEDCHEM
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| 出版日期 | 2011-12-09 |
| 卷号 | 6期号:12页码:2294-2301 |
| 关键词 | alkylating agents anthraquinones anticancer agents cytotoxicity DNA intercalators rhein analogues |
| ISSN号 | 1860-7179 |
| DOI | 10.1002/cmdc.201100384 |
| 文献子类 | Article |
| 英文摘要 | Two series of rhein analogues were synthesized with modification at the 3-position. Their cytotoxicities were evaluated using an MTT assay. Among all the compounds synthesized, one compound showed the best potency, with an IC(50) value of 2.7 mu m against the HeLa cell line and 0.6 mu m against the MOLT4 cell line. |
| WOS关键词 | AMINOANTHRAQUINONE DERIVATIVES ; CELL-GROWTH ; DNA-BINDING ; APOPTOSIS ; ANTHRAQUINONES ; EMODIN ; CYTOTOXICITY ; HYDROXYANTHRAQUINONES ; CARDIOTOXICITY ; GENOTOXICITY |
| 资助项目 | Chinese Academy of Sciences[SIMM0907 KF-08] ; Georgia State University[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000298563400020 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278306]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Chunhao |
| 作者单位 | 1.Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA; 2.Georgia State Univ, Ctr Diagnost & Therapeut, Atlanta, GA 30303 USA; 3.Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 21203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaochuan,Sun, Guojing,Yang, Chunhao,et al. Novel Rhein Analogues as Potential Anticancer Agents[J]. CHEMMEDCHEM,2011,6(12):2294-2301. |
| APA | Yang, Xiaochuan,Sun, Guojing,Yang, Chunhao,&Wang, Binghe.(2011).Novel Rhein Analogues as Potential Anticancer Agents.CHEMMEDCHEM,6(12),2294-2301. |
| MLA | Yang, Xiaochuan,et al."Novel Rhein Analogues as Potential Anticancer Agents".CHEMMEDCHEM 6.12(2011):2294-2301. |
入库方式： OAI收割
来源：上海药物研究所
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