Design, synthesis and biological evaluation of substituted 11H-benzo[a] carbazole-5-carboxamides as novel antitumor agents
文献类型：期刊论文
| 作者 | Wang, Yu-Qin; Li, Xiao-Hua; He, Qian ; Chen, Yi; Xie, Yu-Yuan; Ding, Jian; Miao, Ze-Hong; Yang, Chun-Hao
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| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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| 出版日期 | 2011-12 |
| 卷号 | 46期号:12页码:5878-5884 |
| ISSN号 | 0223-5234 |
| 关键词 | 11H-benzo[a]carbazole Anticancer Synthesis A549 HCT-116 In vivo |
| DOI | 10.1016/j.ejmech.2011.09.050 |
| 文献子类 | Article |
| 英文摘要 | A series of novel 11H-benzo[a]carbazole-5-carboxamide derivatives were designed, synthesized and evaluated for their antitumor activity against human cancer A549 and HCT-116 cell lines. Most of the compounds showed potent antitumor activities, and compound 8 displayed remarkable in vitro and in vivo anticancer activity comparable to that of amonafide. (C) 2011 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | DNA-BINDING PROPERTIES ; ADVANCED BREAST-CANCER ; ACETYLATOR PHENOTYPE ; TOPOISOMERASE-II ; AMONAFIDE ; BISNAPHTHALIMIDES ; NAPHTHALIMIDE ; ANALOGS ; R16 |
| 资助项目 | National Natural Science Foundation of China (NSFC)[81025020] ; National Natural Science Foundation of China (NSFC)[81021062] ; Shanghai Municipality[(09ZR1437900)] ; Shanghai Municipality[SIMM0907 KF-08] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS记录号 | WOS:000297874300017 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278317]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Miao, Ze-Hong |
| 作者单位 | Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yu-Qin,Li, Xiao-Hua,He, Qian,et al. Design, synthesis and biological evaluation of substituted 11H-benzo[a] carbazole-5-carboxamides as novel antitumor agents[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2011,46(12):5878-5884. |
| APA | Wang, Yu-Qin.,Li, Xiao-Hua.,He, Qian.,Chen, Yi.,Xie, Yu-Yuan.,...&Yang, Chun-Hao.(2011).Design, synthesis and biological evaluation of substituted 11H-benzo[a] carbazole-5-carboxamides as novel antitumor agents.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,46(12),5878-5884. |
| MLA | Wang, Yu-Qin,et al."Design, synthesis and biological evaluation of substituted 11H-benzo[a] carbazole-5-carboxamides as novel antitumor agents".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 46.12(2011):5878-5884. |
入库方式： OAI收割
来源：上海药物研究所
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