Synthesis of novel 6-triazologlycolipids via click chemistry and their preliminary cytotoxicity assessments
文献类型：期刊论文
| 作者 | Zhang, Hai-Lin1; He, Xiao-Peng1,3; Sheng, Li2; Yao, Yuan1; Zhang, Wei2; Shi, Xiao-Xin1; Li, Jia2 ; Chen, Guo-Rong1
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| 刊名 | MOLECULAR DIVERSITY
 |
| 出版日期 | 2011-11 |
| 卷号 | 15期号:4页码:889-900 |
| 关键词 | Glycolipid Click reaction Triazole Cytotoxicity MTT assay |
| ISSN号 | 1381-1991 |
| DOI | 10.1007/s11030-011-9318-1 |
| 文献子类 | Article |
| 英文摘要 | Series of novel 6-triazole-linked galacto- or glucolipids were efficiently synthesized from O-benzylated sugar azides and various lipid alkynes via Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (click chemistry) followed by hydrogenolysis with PdCl2/H-2. Subsequent MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay toward a panel of human cancer cell lines revealed that these triazologlycolipids possess low-to-modest toxicity on A549 (lung), MCF-7 (breast), HeLa (cervix), and HepG2 (liver). Furthermore, both the carbon chain length at the lipid end and the epimeric identity of the glycosyl moiety were determined to impact their corresponding bioactivity. |
| WOS关键词 | BIOLOGICAL EVALUATION ; GLYCOLIPIDS ; INHIBITORS ; CYCLOADDITION ; FRACTION ; SPINACH ; DIMERS ; POTENT ; AZIDES ; CELLS |
| 资助项目 | National Natural Science Foundation of China[20876045] ; National Natural Science Foundation of China[30801405] ; National Basic Research Program of China[2007CB914201] ; National Science & Technology Major Project of China[2009ZX09302-001] ; Shanghai Science and Technology Community[10410702700] ; Shanghai Science and Technology Community[09DZ2291200] ; Chinese Academy of Sciences[KSCX2-YW-R-168] ; Fundamental Research Funds for the Central Universities[WK1013002] ; French Embassy in Beijing, P.R. China[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000300364700007 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278341]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 药物安全性评价中心 |
| 通讯作者 | Chen, Guo-Rong |
| 作者单位 | 1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 2.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 3.ENS Cachan, PPSM, CNRS, F-94230 Cachan, France |
| 推荐引用方式 GB/T 7714 | Zhang, Hai-Lin,He, Xiao-Peng,Sheng, Li,et al. Synthesis of novel 6-triazologlycolipids via click chemistry and their preliminary cytotoxicity assessments[J]. MOLECULAR DIVERSITY,2011,15(4):889-900. |
| APA | Zhang, Hai-Lin.,He, Xiao-Peng.,Sheng, Li.,Yao, Yuan.,Zhang, Wei.,...&Chen, Guo-Rong.(2011).Synthesis of novel 6-triazologlycolipids via click chemistry and their preliminary cytotoxicity assessments.MOLECULAR DIVERSITY,15(4),889-900. |
| MLA | Zhang, Hai-Lin,et al."Synthesis of novel 6-triazologlycolipids via click chemistry and their preliminary cytotoxicity assessments".MOLECULAR DIVERSITY 15.4(2011):889-900. |
入库方式： OAI收割
来源：上海药物研究所
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