Domino Reaction to Functionalized 2-Hydroxybenzophenones from Electron-Deficient Chromones and 1,3-Dicarbonyl Compounds
文献类型：期刊论文
| 作者 | Chen, Hong; Xie, Fuchun; Gong, Jian; Hu, Youhong
|
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2011-10-21 |
| 卷号 | 76期号:20页码:8495-8500 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/jo201384f |
| 文献子类 | Article |
| 英文摘要 | A base-promoted one-pot tandem reaction sequence has been developed to transform electron-deficient chromone-fused dienes 1 and 1,3-dicarbonyl compounds 2 to functionalized 2-hydroxybenzophenones 3 under mild conditions. This domino process, which involves multiple reactions, including Michael addition/cyclization/elimination, serves as an efficient, economic, and eco-friendly method for the construction of diversified 2-hydroxybenzophenone scaffolds without a transition-metal catalyst and inert atmosphere. |
| WOS关键词 | DIELS-ALDER REACTIONS ; ONE-POT SYNTHESIS ; 1,3-BIS-SILYL ENOL ETHERS ; MICROWAVE IRRADIATION ; ALDOL REACTIONS ; EFFICIENT SYNTHESIS ; HYPERVALENT IODINE ; COUPLING REACTION ; TANDEM REACTION ; BENZOPHENONES |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1004KF-18] ; National Natural Science Foundation of China[30873142] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000295816700041 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278369]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Hu, Youhong |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Hong,Xie, Fuchun,Gong, Jian,et al. Domino Reaction to Functionalized 2-Hydroxybenzophenones from Electron-Deficient Chromones and 1,3-Dicarbonyl Compounds[J]. JOURNAL OF ORGANIC CHEMISTRY,2011,76(20):8495-8500. |
| APA | Chen, Hong,Xie, Fuchun,Gong, Jian,&Hu, Youhong.(2011).Domino Reaction to Functionalized 2-Hydroxybenzophenones from Electron-Deficient Chromones and 1,3-Dicarbonyl Compounds.JOURNAL OF ORGANIC CHEMISTRY,76(20),8495-8500. |
| MLA | Chen, Hong,et al."Domino Reaction to Functionalized 2-Hydroxybenzophenones from Electron-Deficient Chromones and 1,3-Dicarbonyl Compounds".JOURNAL OF ORGANIC CHEMISTRY 76.20(2011):8495-8500. |
入库方式： OAI收割
来源：上海药物研究所
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