Advances in Small-Molecule Inhibitors of Protein Tyrosine Kinases
文献类型：期刊论文
| 作者 | Wang Yong; Long Yaqiu |
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2011-10 |
| 卷号 | 31期号:10页码:1595-1606 |
| 关键词 | tyrosine kinases inhibitors cancer DFG motif molecular targeted therapy |
| ISSN号 | 0253-2786 |
| 文献子类 | Article |
| 英文摘要 | Protein tyrosine kinases (PTKs) play a pivotal role in the signal transduction pathways, and their deregulation is highly related with the oncology including bladder, breast, colon, and lung cancers. Compounds that inhibit the kinase activity of PTKs are potential chemotherapeutics to treat tumors. With the emergence of the multiple drug resistance of tumor cells against the existing PTK inhibitors, new mechanism PTK inhibitors are designed and developed. This review is focused on the recent advance of the discovery and development of the small molecular PTK inhibitors, categorized according to the mode of action. Furthermore, the synthesis of the typical structures is described. |
| WOS关键词 | CHRONIC MYELOID-LEUKEMIA ; CELL LUNG-CANCER ; BCR-ABL ; STRUCTURAL BASIS ; RATIONAL DESIGN ; RECEPTOR ; POTENT ; DOMAIN ; PROLIFERATION ; ANGIOGENESIS |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4340448 |
| WOS记录号 | WOS:000296679700007 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278376]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang Yong |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Yong,Long Yaqiu. Advances in Small-Molecule Inhibitors of Protein Tyrosine Kinases[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2011,31(10):1595-1606. |
| APA | Wang Yong,&Long Yaqiu.(2011).Advances in Small-Molecule Inhibitors of Protein Tyrosine Kinases.CHINESE JOURNAL OF ORGANIC CHEMISTRY,31(10),1595-1606. |
| MLA | Wang Yong,et al."Advances in Small-Molecule Inhibitors of Protein Tyrosine Kinases".CHINESE JOURNAL OF ORGANIC CHEMISTRY 31.10(2011):1595-1606. |
入库方式： OAI收割
来源：上海药物研究所
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