Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault
文献类型：期刊论文
| 作者 | Li, Liang2,3 ; Sheng, Li3; Wang, Chang-Yun2; Zhou, Yu-Bo3; Huang, Hui4; Li, Xiu-Bao4; Li, Jia3; Mollo, Ernesto1; Gavagnin, Margherita1; Guo, Yue-Wei3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2011-10 |
| 卷号 | 74期号:10页码:2089-2094 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np2003325 |
| 文献子类 | Article |
| 英文摘要 | Two new prenylgermacrane-type diterpenoids, lobophytumins A and B (1 and 2), two new prenyleudesmane-type diterpenoids, lobophytumins C and D (3 and 4), and two new spatane-type diterpenoids, lobophytumins E and F (5 and 6), were isolated from the Hainan soft coral Lobophytum crista turn Tixier-Durivault. Their structures, including relative configuration, were elucidated by detailed analysis of spectroscopic data and by comparison with related known compounds. In addition, the absolute configuration of lobophytumin C (3) was tentatively assigned by comparing its specific rotation with that of the closely related model compound (-)-beta-selinene (8). On the basis of biogenetic considerations, the absolute configurations of lobophytumins A, B, and D F were also tentatively suggested. This is the first report of spatane-type diterpenoids from a soft coral source. The present work supports Faulkner's proposal of prenylgermacrene as the precursor of many diterpenes. In a bioassay, lobophytumins C and D (3 and 4) showed weak in vitro cytotoxicities against the tumor cell lines A-549 and HCT-116. |
| WOS关键词 | SOUTH CHINA SEA ; MARINE NATURAL-PRODUCTS ; SARCOPHYTON-LATUM ; METABOLITES ; PRECURSOR ; CRASSUM ; ASSAY |
| 资助项目 | National Marine "863" Project[2011AA09070102] ; Natural Science Foundation of China[21072204] ; Natural Science Foundation of China[30730108] ; Natural Science Foundation of China[21021063] ; Natural Science Foundation of China[41130858] ; NSFC-TRF[20911140471] ; EU[00000000] ; SIMM/China[10540702900] ; ICB/Italy[10540702900] ; Hungarian-Chinese Intergovernmental S&T Cooperation Programme[00000000] ; SKLDR/SIMM[SIMM1105KF-04] ; SKLDR/SIMM[SIMM1106KF-11] ; CAS[KSCX2-YW-R-18] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000296206500008 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278378]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 上海药物代谢研究中心 |
| 通讯作者 | Wang, Chang-Yun |
| 作者单位 | 1.CNR, Ist Chim Biomol, I-80078 Pozzuoli, Na, Italy 2.Ocean Univ China, Key Lab Marine Drugs, Sch Med & Pharm, Minist Educ, Qingdao, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510000, Guangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Liang,Sheng, Li,Wang, Chang-Yun,et al. Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(10):2089-2094. |
| APA | Li, Liang.,Sheng, Li.,Wang, Chang-Yun.,Zhou, Yu-Bo.,Huang, Hui.,...&Guo, Yue-Wei.(2011).Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault.JOURNAL OF NATURAL PRODUCTS,74(10),2089-2094. |
| MLA | Li, Liang,et al."Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault".JOURNAL OF NATURAL PRODUCTS 74.10(2011):2089-2094. |
入库方式： OAI收割
来源：上海药物研究所
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