Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring
文献类型：期刊论文
| 作者 | Zhang, Zhi-Yun1,2; Zeng, Jin-Jing1,2; Kjaergaard, Marina3; Guan, Ni1,2; Raun, Kirsten3; Nilsson, Cecilia3; Wang, Ming-Wei1,2
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| 刊名 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
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| 出版日期 | 2011-09 |
| 卷号 | 38期号:9页码:613-622 |
| 关键词 | bodyweight chocolate fat metabolism fructose maternal supplemental diet metabolic programming rat |
| ISSN号 | 0305-1870 |
| DOI | 10.1111/j.1440-1681.2011.05568.x |
| 文献子类 | Article |
| 英文摘要 | 1. Consumption of a high-fat and high-energy diet during pregnancy leads to a risk of long-term consequences on fetal development, as well as on the postnatal health of offspring. To investigate the effects of such a diet on fetal programming, we established a high-energy intake pregnant rat model using chocolate and fructose beverage as supplements to a normal chow diet. 2. Pregnant Sprague-Dawley rats were assigned to either chow (control) or a diet supplemented with chocolate and fructose beverage throughout gestation and lactation. The male F(1) pups received normal chow diet after weaning. Physiological or pathological changes in dams and pups (e. g. glucose and lipid metabolism) were evaluated. 3. The results showed that dams offered the high-fat (mainly from chocolate) and high-calorie diet during gestation consumed more energy and gained more weight than chow-fed dams. Over-consumption of chocolate reduced chow intake in dams, leading to low maternal protein supply. As a result, pups from these dams exhibited reduced birth weight that lasted until adulthood. The high-energy diet during lactation led to increased total body fat, as well as impaired liver function, in offspring; thus, the lactational diet is suggested to be a stronger determinant of offspring fat metabolism than gestational diet. 4. The results of the study suggest that over-supply of carbohydrates, such as chocolate and fructose, either during gestation or lactation has a negative impact on the well-being of offspring. |
| WOS关键词 | HIGH-FAT DIET ; PROTEIN RESTRICTION ; INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; PREGNANT RATS ; FOOD-INTAKE ; PPAR-ALPHA ; NUTRITION ; OBESITY ; ACID |
| 资助项目 | CAS[00000000] ; Ministry of Science and Technology of China[2009ZX09302-001] |
| WOS研究方向 | Pharmacology & Pharmacy ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000294563600010 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278420]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Ming-Wei |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Novo Nordisk AS, Diabet Res Unit, Malov, Denmark |
| 推荐引用方式 GB/T 7714 | Zhang, Zhi-Yun,Zeng, Jin-Jing,Kjaergaard, Marina,et al. Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2011,38(9):613-622. |
| APA | Zhang, Zhi-Yun.,Zeng, Jin-Jing.,Kjaergaard, Marina.,Guan, Ni.,Raun, Kirsten.,...&Wang, Ming-Wei.(2011).Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,38(9),613-622. |
| MLA | Zhang, Zhi-Yun,et al."Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 38.9(2011):613-622. |
入库方式： OAI收割
来源：上海药物研究所
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