Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance
文献类型：期刊论文
| 作者 | Tang, Xuan1; Zhuang, Jingjing2; Chen, Jing1 ; Yu, Liang1; Hu, Lihong1; Jiang, Hualiang1; Shen, Xu1,2
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| 刊名 | PLOS ONE
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| 出版日期 | 2011-08-26 |
| 卷号 | 6期号:8 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0024224 |
| 文献子类 | Article |
| 英文摘要 | Physical inactivity is considered as one of the potential risk factors for the development of type 2 diabetes and other metabolic diseases, while endurance exercise training could enhance fat oxidation that is associated with insulin sensitivity improvement in obesity. AMP-activated protein kinase (AMPK) as an energy sensor plays pivotal roles in the regulation of energy homeostasis, and its activation could improve glucose uptake, promote mitochondrial biogenesis and increase glycolysis. Recent research has even suggested that AMPK activation contributed to endurance enhancement without exercise. Here we report that the natural product arctigenin from the traditional herb Arctium lappa L. (Compositae) strongly increased AMPK phosphorylation and subsequently up-regulated its downstream pathway in both H9C2 and C2C12 cells. It was discovered that arctigenin phosphorylated AMPK via calmodulin-dependent protein kinase kinase (CaMKK) and serine/threonine kinase 11(LKB1)-dependent pathways. Mice treadmill based in vivo assay further indicated that administration of arctigenin improved efficiently mice endurance as reflected by the increased fatigue time and distance, and potently enhanced mitochondrial biogenesis and fatty acid oxidation (FAO) related genes expression in muscle tissues. Our results thus suggested that arctigenin might be used as a potential lead compound for the discovery of the agents with mimic exercise training effects to treat metabolic diseases. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; HUMAN SKELETAL-MUSCLE ; COACTIVATOR 1-ALPHA PGC-1-ALPHA ; TRANSCRIPTIONAL COACTIVATOR ; INSULIN SENSITIVITY ; ENERGY-METABOLISM ; MITOCHONDRIAL BIOGENESIS ; UPSTREAM KINASE ; IN-VIVO ; EXERCISE |
| 资助项目 | State Key Program of Basic Research of China[2010CB912501] ; State Key Program of Basic Research of China[2007CB914304] ; State Key Program of Basic Research of China[2009CB918502] ; National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[30890044] ; National Natural Science Foundation of China[10979072] ; Science Foundation of Shanghai[08431902900] ; Foundation of Chinese Academy of Sciences[KSCX2-YW-R-168] ; Foundation of Chinese Academy of Sciences[SCX1-YW-02-2] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000294298800038 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278430]  |
| 专题 | 药物安全性评价中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第三研究室 上海中药现代化研究中心 |
| 通讯作者 | Tang, Xuan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Xuan,Zhuang, Jingjing,Chen, Jing,et al. Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance[J]. PLOS ONE,2011,6(8). |
| APA | Tang, Xuan.,Zhuang, Jingjing.,Chen, Jing.,Yu, Liang.,Hu, Lihong.,...&Shen, Xu.(2011).Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance.PLOS ONE,6(8). |
| MLA | Tang, Xuan,et al."Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance".PLOS ONE 6.8(2011). |
入库方式： OAI收割
来源：上海药物研究所
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