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Preparation of alpha-Alkyl-beta-Amino Acids via beta-Alanine Ni(II) Complex

文献类型：期刊论文

作者Lin, Daizong1; Lv, Li2; Wang, Jiang1; Ding, Xiao1; Jiang, Hualiang1; Liu, Hong1
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2011-08-19
卷号76期号:16页码:6649-6656
ISSN号0022-3263
DOI10.1021/jo200971k
文献子类Article
英文摘要A new beta-amino acrylic acid Ni(II) complex has been developed and used for the synthesis of alpha-alkyl-beta-amino acids via alkylation with alkyl halides under operationally convenient conditions. The pivotal alpha-alkylated intermediate can be converted into the corresponding alpha-alkyl-beta-amino acids via two steps with a wide range of substituents.
WOS关键词BAYLIS-HILLMAN REACTION ; MICHAEL ADDITION-REACTIONS ; EFFICIENT SYNTHESIS ; NUCLEOPHILIC GLYCINE ; ASYMMETRIC-SYNTHESIS ; NICKEL(II) COMPLEXES ; PYROGLUTAMIC ACIDS ; GENERAL-METHOD ; ONE-POT ; BASE
资助项目National Natural Science Foundation of China[20872153] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[20720102040] ; National Natural Science Foundation of China[81025017] ; State Key Program of Basic Research of China[2009CB918502] ; Chinese Academy of Sciences[XDA01040305]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000293759000018
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/278434]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Liu, Hong
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China;
2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式
GB/T 7714		 Lin, Daizong,Lv, Li,Wang, Jiang,et al. Preparation of alpha-Alkyl-beta-Amino Acids via beta-Alanine Ni(II) Complex[J]. JOURNAL OF ORGANIC CHEMISTRY,2011,76(16):6649-6656.
APA Lin, Daizong,Lv, Li,Wang, Jiang,Ding, Xiao,Jiang, Hualiang,&Liu, Hong.(2011).Preparation of alpha-Alkyl-beta-Amino Acids via beta-Alanine Ni(II) Complex.JOURNAL OF ORGANIC CHEMISTRY,76(16),6649-6656.
MLA Lin, Daizong,et al."Preparation of alpha-Alkyl-beta-Amino Acids via beta-Alanine Ni(II) Complex".JOURNAL OF ORGANIC CHEMISTRY 76.16(2011):6649-6656.

入库方式： OAI收割

来源：上海药物研究所

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