Solvent-free synthesis of delta-carbolines/carbazoles from 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives using DPPE as a reducing agent
文献类型：期刊论文
| 作者 | Peng, Haixia; Chen, Xuxing; Chen, Yanhong; He, Qian ; Xie, Yuyuan; Yang, Chunhao
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2011-08-12 |
| 卷号 | 67期号:32页码:5725-5731 |
| 关键词 | Solvent-free delta-Carbolines Carbazoles Cadogen cyclization DPPE |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2011.06.027 |
| 文献子类 | Article |
| 英文摘要 | A green and efficient preparation of functionalized delta-carbolines/carbazoles via reductive ring closure by 1,2-bis(dipenylphosphino)ethane under solvent-free conditions is described. The starting materials 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives are readily prepared through Suzuki-Miyaura cross-coupling reaction from commercially available compounds. And the polar by-product ethane-1,2-diylbis(diphenylphosphine oxide) is easily removed from the relatively polar reaction mixture. Various substituted delta-carbolines/carbazoles are obtained in acceptable yields. It is particularly worth mentioning that substrates with electron-withdrawing groups (EWG) also give the desired products in good yield. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | INDOLOQUINOLINE ALKALOIDS ; REDUCTIVE CYCLIZATION ; CONVENIENT SYNTHESIS ; TRIETHYL PHOSPHITE ; DIRECT ARYLATION ; GAMMA-CARBOLINE ; NITRO-COMPOUNDS ; ARYL AZIDES ; CARBAZOLES ; INDOLES |
| 资助项目 | National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2009ZX09301-001] ; National Natural Science Foundation of China[21072205] ; Shanghai Municipality Science and Technology[09JC1416600] ; Shanghai Municipality Science and Technology[09ZR1437900] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000293119900002 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278441]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Chunhao |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Haixia,Chen, Xuxing,Chen, Yanhong,et al. Solvent-free synthesis of delta-carbolines/carbazoles from 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives using DPPE as a reducing agent[J]. TETRAHEDRON,2011,67(32):5725-5731. |
| APA | Peng, Haixia,Chen, Xuxing,Chen, Yanhong,He, Qian,Xie, Yuyuan,&Yang, Chunhao.(2011).Solvent-free synthesis of delta-carbolines/carbazoles from 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives using DPPE as a reducing agent.TETRAHEDRON,67(32),5725-5731. |
| MLA | Peng, Haixia,et al."Solvent-free synthesis of delta-carbolines/carbazoles from 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives using DPPE as a reducing agent".TETRAHEDRON 67.32(2011):5725-5731. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。