New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis
文献类型：期刊论文
| 作者 | Hu, Xiao1; Ji, Jun1; Wang, Meng1; Wu, Jin-Wei2; Zhao, Qin-Shi3; Wang, He-Yao2 ; Hou, Ai-Jun1
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2011-08-01 |
| 卷号 | 21期号:15页码:4441-4446 |
| 关键词 | Morus notabilis Isoprenylated flavonoids Adipogenesis |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2011.06.020 |
| 文献子类 | Article |
| 英文摘要 | Five new isoprenylated flavonoids, notabilisins A-E (1-5), and two known Diels-Alder adducts (6 and 7), were isolated from the twigs of Morus notabilis. Compounds 4 and 5 possess two novel pyran rings, which may be biogenetically derived from 3. Compounds 1 and 3 significantly promoted adipogenesis, characterized by increased lipid droplet and triglyceride content in 3T3L1 cells, and induced up-regulation of the expression of adipocyte-specific genes, aP2 and GLUT4. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ALDER-TYPE ADDUCTS ; ROOT BARK ; ANTIOXIDANT ; ALBA |
| 资助项目 | National Natural Science Foundation of China[21072035] ; program for New Century Excellent Talents in University[NCET-09-0313] ; National Drug Innovative Program[2009ZX09301-011] ; State Key Laboratory of Phytochemistry and Plant Resources in West China (Kunming Institute of Botany, Chinese Academy of Sciences)[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000292729900012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278461]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Hou, Ai-Jun |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiao,Ji, Jun,Wang, Meng,et al. New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(15):4441-4446. |
| APA | Hu, Xiao.,Ji, Jun.,Wang, Meng.,Wu, Jin-Wei.,Zhao, Qin-Shi.,...&Hou, Ai-Jun.(2011).New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(15),4441-4446. |
| MLA | Hu, Xiao,et al."New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.15(2011):4441-4446. |
入库方式： OAI收割
来源：上海药物研究所
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