Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability
文献类型：期刊论文
| 作者 | Li, Jing1 ; Dai, Gong1; Cheng, Ya-Bin1; Qi, Xin1; Geng, Mei-Yu1,2
|
| 刊名 | GLYCOBIOLOGY
 |
| 出版日期 | 2011-08 |
| 卷号 | 21期号:8页码:1010-1018 |
| 关键词 | adhesion FGFR migration NCAM PSA |
| ISSN号 | 0959-6658 |
| DOI | 10.1093/glycob/cwr020 |
| 文献子类 | Article |
| 英文摘要 | Polysialic acid (PSA), a carbohydrate polymer mainly present in the neural cell adhesion molecule (NCAM), promotes neural plasticity; however, its mode of action in tumor malignancy remains largely unknown. In this study, we investigated the influence of polysialylation on cell migration. PSA consistently promoted cell migration on different extracellular matrices (ECMs) but differentially affected cell adhesion. All of these actions were reversed by endo-N-acetylneuraminidase treatment, and PSA-driven migration was inhibited by the specific fibroblast growth factor receptor (FGFR) inhibitor Su5402. Consistent with this latter observation, PSA-stimulated migration on different ECMs was paralleled by activation of the FGFR and its downstream signaling components, PLC-gamma, focal adhesion kinase and extracellular signal-regulated kinase 1/2. In contrast, the pattern of p59(fyn) activation correlated with differential adhesion to different ECMs. Collectively, these results indicate that PSA-conjugated NCAM potentiates signal transduction by the FGFR pathway and thereby enhances cell migration independent of adhesion capability, providing additional insights into the role of PSA in cancer development. |
| WOS关键词 | POLYSIALIC ACID EXPRESSION ; NERVOUS-SYSTEM ; BREAST-CANCER ; LUNG-CANCER ; NCAM ; INVASION ; ACTIVATION ; PATHWAYS ; BINDING ; STX |
| 资助项目 | Program for Changjiang Scholars and Innovative Research Team in University[IRT0944] ; Natural Science Foundation of China for Distinguished Young Scholars[30725046] ; State Plan for High-Tech Research and Development of China[2007AA09Z405] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000292557600004 |
| 出版者 | OXFORD UNIV PRESS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278462]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Geng, Mei-Yu |
| 作者单位 | 1.Ocean Univ China, Sch Med & Pharm, Dept Pharmacol & Glycobiol, Qingdao 266003, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, PR, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jing,Dai, Gong,Cheng, Ya-Bin,et al. Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability[J]. GLYCOBIOLOGY,2011,21(8):1010-1018. |
| APA | Li, Jing,Dai, Gong,Cheng, Ya-Bin,Qi, Xin,&Geng, Mei-Yu.(2011).Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability.GLYCOBIOLOGY,21(8),1010-1018. |
| MLA | Li, Jing,et al."Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability".GLYCOBIOLOGY 21.8(2011):1010-1018. |
入库方式： OAI收割
来源：上海药物研究所
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