Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells
文献类型：期刊论文
| 作者 | Lu, Jin-Jian1,2; Cai, Yu-Jun1; Ding, Jian1
|
| 刊名 | MOLECULAR AND CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2011-08 |
| 卷号 | 354期号:1-2页码:247-252 |
| 关键词 | Curcumin DNA damage Caffeine S phase arrest Mitosis arrest Tubulin |
| ISSN号 | 0300-8177 |
| DOI | 10.1007/s11010-011-0824-3 |
| 文献子类 | Article |
| 英文摘要 | Curcumin (CUR), a polyphenol derived from the plant Curcuma longa, displays potential anti-cancer activity. One of the mechanisms stems from its ability to elicit cell cycle arrest followed by suppression of cell proliferation. Herein, we reported that CUR significantly induced DNA damage and mediated S and G2/M phase arrest in colorectal carcinoma HCT116 cells. Unlike etoposide, a classical topoisomerase II inhibitor, CUR-triggered G2/M phase arrest was hardly reversed by caffeine (CAFF) which is an inhibitor of activated ataxia-telangiectasia-mutated (ATM)/ATM- and Rad3-related (ATR), indicating that ATM and ATR signaling pathways may be not involved in CUR-mediated S and G2/M phase arrest in HCT116 cells. Furthermore, we demonstrated that CUR caused mitosis arrest in HCT116 cells by using mitotic protein monoclonal antibody-2 as a mitosis marker and the surface plasmon resonance assay. The findings provide new mechanisms of cell proliferation inhibition triggered by CUR in HCT116 cells. |
| WOS关键词 | S-PHASE ARREST ; CANCER CELLS ; IN-VIVO ; APOPTOSIS ; ACTIVATION ; ATR ; PROLIFERATION ; INHIBITION ; CHECKPOINT ; PROFILES |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000292215600026 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278465]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Cai, Yu-Jun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou 310053, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Jin-Jian,Cai, Yu-Jun,Ding, Jian. Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2011,354(1-2):247-252. |
| APA | Lu, Jin-Jian,Cai, Yu-Jun,&Ding, Jian.(2011).Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells.MOLECULAR AND CELLULAR BIOCHEMISTRY,354(1-2),247-252. |
| MLA | Lu, Jin-Jian,et al."Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells".MOLECULAR AND CELLULAR BIOCHEMISTRY 354.1-2(2011):247-252. |
入库方式： OAI收割
来源：上海药物研究所
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