SKF83959 Suppresses Excitatory Synaptic Transmission in Rat Hippocampus Via a Dopamine Receptor-Independent Mechanism
文献类型：期刊论文
| 作者 | Chu, Hong-Yuan2,3; Wu, Qianqian2,3; Zhou, Shanglin2,3; Cao, Xiaohua4; Zhang, Ao5 ; Jin, Guo-Zhang2,3; Hu, Guo-Yuan2,3; Zhen, Xuechu1,2,3
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| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
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| 出版日期 | 2011-08 |
| 卷号 | 89期号:8页码:1259-1266 |
| 关键词 | excitatory postsynaptic potential neuroprotection Parkinson's disease SKF83959 voltage-gated Na+ channel |
| ISSN号 | 0360-4012 |
| DOI | 10.1002/jnr.22653 |
| 文献子类 | Article |
| 英文摘要 | Dopamine (DA) profoundly modulates excitatory synaptic transmission and synaptic plasticity in the brain. In the present study the effects of SKF83959, the selective agonist of phosphatidylinositol (PI)-linked D-1-like receptor, on the excitatory synaptic transmission were investigated in rat hippocampus. SKF83959 (10-100 mu M) reversibly suppressed the field excitatory postsynaptic potential (fEPSP) elicited by stimulating the Schaffer's collateral-commissural fibers in CA1 area of hippocampal slices. However, the inhibition was not blocked by the D-1 receptor antagonist SCH23390, the D-2 receptor antagonist raclopride, the 5-HT2A/2C receptor antagonist mesulergine, or the alpha(1)-adrenoceptor antagonist prazosin. In addition, SKF83959 inhibited the afferent volley and significantly reduced the paired-pulse facilitation ratios. In dissociated hippocampal CA1 pyramidal neurons, SKF83959 had no detectable effect on glutamate-induced currents but potently inhibited voltage-activated Na+ current (IC50 value = 26.9 +/- 1.0 mu M), which was not blocked by SCH23390 or by intracellular dialysis of GDP-beta-S. These results demonstrate that SKF83959 suppressed the excitatory synaptic transmission in hippocampal CA1 area, which was independent of D-1-like receptor. The mechanism underlying the effect could be mainly inhibition of Na+ channel in the afferent fibers. The suppression of excitatory synaptic transmission and the Na+ channel by SKF83959 may contribute to its therapeutic benefits in Parkinson's disease. (C) 2011 Wiley-Liss, Inc. |
| WOS关键词 | LONG-TERM POTENTIATION ; K+ CHANNEL ; PREFRONTAL CORTEX ; D1-LIKE RECEPTORS ; PYRAMIDAL NEURONS ; MESSENGER-RNA ; NA+ CHANNELS ; SKF 83959 ; I-H ; BRAIN |
| 资助项目 | Ministry of Science and Technology of China[2007AA02z163] ; Ministry of Science and Technology of China[2009CB522000] ; Natural Science Foundation of China[30770662] ; Natural Science Foundation of China[30825042] ; Natural Science Foundation of China[20872153] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000291704400012 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278466]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhen, Xuechu |
| 作者单位 | 1.Soochow Univ, Coll Pharm, Dept Pharmacol, Suzhou, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol 2, Shanghai 201203, Peoples R China; 4.Eastern China Normal Univ, Brain Funct Genom Inst, Shanghai, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chu, Hong-Yuan,Wu, Qianqian,Zhou, Shanglin,et al. SKF83959 Suppresses Excitatory Synaptic Transmission in Rat Hippocampus Via a Dopamine Receptor-Independent Mechanism[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2011,89(8):1259-1266. |
| APA | Chu, Hong-Yuan.,Wu, Qianqian.,Zhou, Shanglin.,Cao, Xiaohua.,Zhang, Ao.,...&Zhen, Xuechu.(2011).SKF83959 Suppresses Excitatory Synaptic Transmission in Rat Hippocampus Via a Dopamine Receptor-Independent Mechanism.JOURNAL OF NEUROSCIENCE RESEARCH,89(8),1259-1266. |
| MLA | Chu, Hong-Yuan,et al."SKF83959 Suppresses Excitatory Synaptic Transmission in Rat Hippocampus Via a Dopamine Receptor-Independent Mechanism".JOURNAL OF NEUROSCIENCE RESEARCH 89.8(2011):1259-1266. |
入库方式： OAI收割
来源：上海药物研究所
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