Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells
文献类型：期刊论文
| 作者 | Zhao, Qian1; Guo, Yuewei2 ; Feng, Bo1; Li, Liang2; Huang, Caiguo1; Jiao, Binghua1
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2011-07 |
| 卷号 | 82期号:5页码:735-741 |
| 关键词 | HepG2 Cell cycle arrest Apoptosis Fas FasL Caspases |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2011.03.004 |
| 文献子类 | Article |
| 英文摘要 | The effects of neriifolin, a cardiac glycoside from Cerbera manghas L on various end-points of oncologic relevance (cell growth, cell cycle regulation, and apoptosis in HepG2 cells) were investigated. Neriifolin reduced viability of HepG2 cells, induced S and G2/M phase arrests of the cell cycle, and stimulated apoptosis of HepG2 cells. Stimulation of HepG2 cells with neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins. Based on these results, neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. (C) 2011 Elsevier B.V. All rights reserved. |
| WOS关键词 | DRUG-INDUCED APOPTOSIS ; APO-1/FAS RECEPTOR/LIGAND SYSTEM ; CARDIAC-GLYCOSIDES ; THEVETIA-PERUVIANA ; CANCER ; FAS ; ACTIVATION ; DEATH ; LIGAND ; PROLIFERATION |
| 资助项目 | National Basic Research Program of China (973 Program)[2010CB833804] ; 863 Program[2011AA090701] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000292123100002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278489]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 上海药物代谢研究中心 |
| 通讯作者 | Huang, Caiguo |
| 作者单位 | 1.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Qian,Guo, Yuewei,Feng, Bo,et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[J]. FITOTERAPIA,2011,82(5):735-741. |
| APA | Zhao, Qian,Guo, Yuewei,Feng, Bo,Li, Liang,Huang, Caiguo,&Jiao, Binghua.(2011).Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.FITOTERAPIA,82(5),735-741. |
| MLA | Zhao, Qian,et al."Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells".FITOTERAPIA 82.5(2011):735-741. |
入库方式： OAI收割
来源：上海药物研究所
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