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An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization

文献类型：期刊论文

作者Zhang, Xu1,2; Zhou, Yu1; Wang, Hengshuai1; Guo, Diliang1,2; Ye, Deju1; Xu, Yungen2; Jiang, Hualiang1; Liu, Hong1,2
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2011-06
卷号353期号:9页码:1429-1437
关键词cyclization fused benzimidazoles iodine silver nitrate
ISSN号1615-4150
DOI10.1002/adsc.201100038
文献子类Article
英文摘要A protocol for the synthesis of the fused heterocyclic polycyclic compounds pyrrole[1,2-a]benzimidazoles, piperidine[1,2-a]benzimidazoles and oxa-fused benzimidazoles using iodine and silver nitrate by an exo-dig or endo-dig cyclization pathway at room temperature has been developed. Silver nitrate is a key additive for improving the yield, and the improvement is a result of this additive eliminating the influence of iodine ions (I(-)), which would otherwise lead to the formation of bis-iodine by-products. Cyclizations involving terminal and substituted alkynes were performed. Further functionalizations demonstrated that the iodo derivatives obtained are potential synthetic intermediates that can increase the molecular complexity.
WOS关键词MEDIATED ELECTROPHILIC CYCLIZATION ; ANTITUMOR AGENTS ; HETEROCYCLES ; IODINE ; ISOQUINOLINES ; DERIVATIVES ; INHIBITORS ; AROMATICS ; ANALOGS ; ALKYNES
资助项目National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[20872153] ; National Natural Science Foundation of China[81025017]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000292848200008
出版者WILEY-BLACKWELL
源URL[http://119.78.100.183/handle/2S10ELR8/278507]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药物发现与设计中心
通讯作者Liu, Hong
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xu,Zhou, Yu,Wang, Hengshuai,et al. An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization[J]. ADVANCED SYNTHESIS & CATALYSIS,2011,353(9):1429-1437.
APA Zhang, Xu.,Zhou, Yu.,Wang, Hengshuai.,Guo, Diliang.,Ye, Deju.,...&Liu, Hong.(2011).An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization.ADVANCED SYNTHESIS & CATALYSIS,353(9),1429-1437.
MLA Zhang, Xu,et al."An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization".ADVANCED SYNTHESIS & CATALYSIS 353.9(2011):1429-1437.

入库方式： OAI收割

来源：上海药物研究所

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