CONVENIENT ONE-POT SYNTHESIS OF 3-ARYL-2H-CHROMENE-4-CARBONITRILES VIA A TANDEM O-ALKYLATION-KNOEVENAGEL CONDENSATION
文献类型：期刊论文
| 作者 | Chen, Yanhong; Xiang, Haoyue; Xie, Yuyuan ; Yang, Chunhao
|
| 刊名 | HETEROCYCLES
 |
| 出版日期 | 2011-06-01 |
| 卷号 | 83期号:6页码:1355-1361 |
| 关键词 | One-Pot Synthesis 3-Aryl-2H-chromene-4-carbonitrile o-Alkylation Knoevenagel Condensation Tandem Reaction |
| ISSN号 | 0385-5414 |
| DOI | 10.3987/COM-11-12203 |
| 文献子类 | Article |
| 英文摘要 | 3-Aryl-2H-chromene-4-carbonitriles were synthesized through one-pot tandem reaction of easily available 2-(2-hydroxyphenyl)acetonitrile (1) and 2-bromo-1-arylethanones (2) under the condition of K(2)CO(3)/dioxane. These functionalized chromenes could be useful building-blocks for estrogen receptor ligands and other related heterocycles. |
| WOS关键词 | POTASSIUM CHANNEL ACTIVATORS ; ANTIHYPERTENSIVE ACTIVITY ; DERIVATIVES ; DISCOVERY ; RING |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09301-001] ; National Natural Science Foundation of China[21072205] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000292671600011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278509]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Chen, Yanhong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, SIBS, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yanhong,Xiang, Haoyue,Xie, Yuyuan,et al. CONVENIENT ONE-POT SYNTHESIS OF 3-ARYL-2H-CHROMENE-4-CARBONITRILES VIA A TANDEM O-ALKYLATION-KNOEVENAGEL CONDENSATION[J]. HETEROCYCLES,2011,83(6):1355-1361. |
| APA | Chen, Yanhong,Xiang, Haoyue,Xie, Yuyuan,&Yang, Chunhao.(2011).CONVENIENT ONE-POT SYNTHESIS OF 3-ARYL-2H-CHROMENE-4-CARBONITRILES VIA A TANDEM O-ALKYLATION-KNOEVENAGEL CONDENSATION.HETEROCYCLES,83(6),1355-1361. |
| MLA | Chen, Yanhong,et al."CONVENIENT ONE-POT SYNTHESIS OF 3-ARYL-2H-CHROMENE-4-CARBONITRILES VIA A TANDEM O-ALKYLATION-KNOEVENAGEL CONDENSATION".HETEROCYCLES 83.6(2011):1355-1361. |
入库方式： OAI收割
来源：上海药物研究所
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