Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules
文献类型：期刊论文
| 作者 | Zhou, Ping-zheng1,2; Babcock, Joseph3,4; Liu, Lian-qing2; Li, Min1,3,4; Gao, Zhao-bing1
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2011-06 |
| 卷号 | 32期号:6页码:781-788 |
| 关键词 | Human ether-a-go-go related gene (hERG) ion channel long QT syndrome (LQTS) activator |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2011.70 |
| 文献子类 | Review |
| 英文摘要 | Human ether-a-go-go related gene (hERG) potassium (K+) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS). Moreover, the channels can be inhibited by structurally diverse small molecules, resulting in an acquired form of LQTS. Consequently, small molecules that increase the hERG current may be of value for treatment of LQTS. So far, nine hERG activators have been reported. The aim of this review is to discuss recent advances concerning the identification and action mechanism of hERG activators. |
| WOS关键词 | LONG-QT SYNDROME ; ACQUIRED CARDIAC-ARRHYTHMIA ; K+ CHANNEL ; STRUCTURAL BASIS ; MECHANISMS ; THERAPY ; INACTIVATION ; MUTATIONS |
| 资助项目 | National Natural Science Foundation of China[81072579] ; State Key Laboratory of Robotics[RLO201013] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000291304000015 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278511]  |
| 专题 | 神经药理学研究国际科学家工作站 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Gao, Zhao-bing |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shenyang Inst Automat, State Key Lab Robot, Shenyang 110016, Peoples R China; 3.Johns Hopkins Univ, Johns Hopkins Ion Channel Ctr, Sch Med, Baltimore, MD 21205 USA; 4.Johns Hopkins Univ, High Throughput Biol Ctr, Dept Neurosci, Baltimore, MD 21205 USA |
| 推荐引用方式 GB/T 7714 | Zhou, Ping-zheng,Babcock, Joseph,Liu, Lian-qing,et al. Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules[J]. ACTA PHARMACOLOGICA SINICA,2011,32(6):781-788. |
| APA | Zhou, Ping-zheng,Babcock, Joseph,Liu, Lian-qing,Li, Min,&Gao, Zhao-bing.(2011).Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules.ACTA PHARMACOLOGICA SINICA,32(6),781-788. |
| MLA | Zhou, Ping-zheng,et al."Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules".ACTA PHARMACOLOGICA SINICA 32.6(2011):781-788. |
入库方式： OAI收割
来源：上海药物研究所
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