Antitussive Indole Alkaloids from Kopsia hainanensis
文献类型：期刊论文
| 作者 | Tan, Min-Jia1,2 ; Yin, Chun; Tang, Chun-Ping2; Ke, Chang-Qiang2; Lin, Ge1; Ye, Yang2
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2011-06 |
| 卷号 | 77期号:9页码:939-944 |
| 关键词 | Kopsia hainanensis Apocynaceae danuphyllin type aspidofractinine type chanofruticosinate type antitussive activity |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0030-1250631 |
| 文献子类 | Article |
| 英文摘要 | Three new indole alkaloids, named kopsihainins A-C (1-3), and two known compounds, kopsinine (4) and methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and 5 exhibited significant antitussive activity in a citric acid induced guinea pig cough model. The antitussive effect of 4 was demonstrated to interact with the delta-opioid receptor. This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids. |
| WOS关键词 | OPIOID RECEPTOR ANTAGONISTS ; BIOLOGICALLY-ACTIVE ASPIDOFRACTININE ; MESSAGE ADDRESS CONCEPT ; STEMONA-TUBEROSA ; GUINEA-PIGS ; ROOTS ; NALTRINDOLE ; DESIGN ; POTENT ; LEAVES |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09301-001] ; Ministry of Science and Technology[2007DFC31030] ; Shanghai Commission of Science and Technology[08DZ1971401] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000292028900011 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278519]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 化学蛋白质组学研究中心 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res & Nat Prod, Dept Chem, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Tan, Min-Jia,Yin, Chun,Tang, Chun-Ping,et al. Antitussive Indole Alkaloids from Kopsia hainanensis[J]. PLANTA MEDICA,2011,77(9):939-944. |
| APA | Tan, Min-Jia,Yin, Chun,Tang, Chun-Ping,Ke, Chang-Qiang,Lin, Ge,&Ye, Yang.(2011).Antitussive Indole Alkaloids from Kopsia hainanensis.PLANTA MEDICA,77(9),939-944. |
| MLA | Tan, Min-Jia,et al."Antitussive Indole Alkaloids from Kopsia hainanensis".PLANTA MEDICA 77.9(2011):939-944. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。