Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product
文献类型：期刊论文
| 作者 | Carbone, Marianna2; Li, Yan1; Irace, Carlo3; Mollo, Ernesto2; Castelluccio, Francesco2; Di Pascale, Antonio3; Cimino, Guido2; Santamaria, Rita3; Guo, Yue-Wei1 ; Gavagnin, Margherita2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2011-05-20 |
| 卷号 | 13期号:10页码:2516-2519 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol200234r |
| 文献子类 | Article |
| 英文摘要 | Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor and nontumor mammalian cell lines in in vitro assays. |
| WOS关键词 | INDOLE ALKALOIDS ; BIOISOSTERIC TRANSFORMATIONS ; CARBOXYLIC FUNCTIONALITIES ; DRUG LEADS ; OXADIAZOLES ; RECEPTOR ; POTENT ; DERIVATIVES ; DISCOVERY ; SPONGE |
| 资助项目 | National S & T Major Project[2009ZX09301-001] ; national marine 863 project[2007AA09Z447] ; national marine 863 project[2007AA09Z402] ; NSFC[40976048] ; NSFC[30730108] ; NSFC[20721003] ; NSFC[20772136] ; CAS[KSX2-YW-R-18] ; CAS[SIMM0907KF-09] ; PRIN-MIUR[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000290465800002 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278524]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.CNR, ICB, I-80078 Pozzuoli, NA, Italy; 3.Univ Naples Federico 2, Fac Farm, Dipartimento Farmacol Sperimentale, Naples, Italy |
| 推荐引用方式 GB/T 7714 | Carbone, Marianna,Li, Yan,Irace, Carlo,et al. Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product[J]. ORGANIC LETTERS,2011,13(10):2516-2519. |
| APA | Carbone, Marianna.,Li, Yan.,Irace, Carlo.,Mollo, Ernesto.,Castelluccio, Francesco.,...&Gavagnin, Margherita.(2011).Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product.ORGANIC LETTERS,13(10),2516-2519. |
| MLA | Carbone, Marianna,et al."Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product".ORGANIC LETTERS 13.10(2011):2516-2519. |
入库方式： OAI收割
来源：上海药物研究所
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