Synthesis of Pyrrolo[1,2-a]quinoxalines via Gold(I)-Mediated Cascade Reactions
文献类型：期刊论文
| 作者 | Liu, Guannan1,2; Zhou, Yu1 ; Lin, Daizong1; Wang, Jinfang1; Zhang, Lei1; Jiang, Hualiang1; Liu, Hong1
|
| 刊名 | ACS COMBINATORIAL SCIENCE
 |
| 出版日期 | 2011-05 |
| 卷号 | 13期号:3页码:209-213 |
| 关键词 | gold-catalyst cascade reaction hydroamination hydroarylation |
| ISSN号 | 2156-8952 |
| DOI | 10.1021/co1000844 |
| 文献子类 | Article |
| 英文摘要 | In this study we developed an efficient tandem process of hydroamination and hydoarylation using a, gold catalyst to enable and study the reactions between pyrrole-substituted anilines and alkynes. The gold(I)-catalyzed reactions were achieved in toluene at 80 degrees C over a reaction time of 1-6 h. These reactions are applicable to a variety of aromatic amino compounds and both the terminal and internal,alkynes. Substituted pyrrolo[1,2-a]quinoxalines were obtained in moderate to excellent yields. A presumed mechanism involving intermolecular C-N bond formation and intramolecular nucleophilic reaction via a cationic gold complex has been proposed on the basis of the deuterium labeling studies. |
| WOS关键词 | HOMOGENEOUS GOLD CATALYSIS ; TERMINAL ALKYNES ; ANTIMALARIAL ACTIVITY ; HETEROCYCLES ; BONDS ; HYDROAMINATION ; HYDROARYLATION ; DERIVATIVES ; METATHESIS ; ACTIVATION |
| 资助项目 | National Natural Science Foundation of China[20872153] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[81025017] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000290246300002 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278540]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res,Ctr Drug Discovery & Desig, Shanghai 201203, Peoples R China; 2.China Jiliang Univ, Dept Pharm, Coll Life Sci, Hangzhou 310018, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Guannan,Zhou, Yu,Lin, Daizong,et al. Synthesis of Pyrrolo[1,2-a]quinoxalines via Gold(I)-Mediated Cascade Reactions[J]. ACS COMBINATORIAL SCIENCE,2011,13(3):209-213. |
| APA | Liu, Guannan.,Zhou, Yu.,Lin, Daizong.,Wang, Jinfang.,Zhang, Lei.,...&Liu, Hong.(2011).Synthesis of Pyrrolo[1,2-a]quinoxalines via Gold(I)-Mediated Cascade Reactions.ACS COMBINATORIAL SCIENCE,13(3),209-213. |
| MLA | Liu, Guannan,et al."Synthesis of Pyrrolo[1,2-a]quinoxalines via Gold(I)-Mediated Cascade Reactions".ACS COMBINATORIAL SCIENCE 13.3(2011):209-213. |
入库方式： OAI收割
来源：上海药物研究所
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