Small molecule inhibitors of amyloid beta peptide aggregation as a potential therapeutic strategy for Alzheimer's disease
文献类型：期刊论文
| 作者 | Nie, Qin1; Du, Xiao-guang2; Geng, Mei-yu1,2
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2011-05 |
| 卷号 | 32期号:5页码:545-551 |
| 关键词 | Alzheimer's disease amyloid beta peptide protein-protein interaction small molecule |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2011.14 |
| 文献子类 | Review |
| 英文摘要 | Amyloid beta (A beta) peptides have long been viewed as a potential target for Alzheimer's disease (AD). Aggregation of A beta peptides in the brain tissue is believed to be an exclusively pathological process. Therefore, blocking the initial stages of A beta peptide aggregation with small molecules could hold considerable promise as the starting point for the development of new therapies for AD. Recent rapid progresses in our understanding of toxic amyloid assembly provide a fresh impetus for this interesting approach. Here, we discuss the problems, challenges and new concepts in targeting A beta peptides. |
| WOS关键词 | PROTEIN-PROTEIN INTERACTIONS ; PRECURSOR PROTEIN ; GAMMA-SECRETASE ; PRINCIPLES ; OLIGOMERS ; FRAGMENT |
| 资助项目 | National Natural Science Foundation of China[30472029] ; National Natural Science Foundation of China for Distinguished Young Scholars[30725046] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4190570 |
| WOS记录号 | WOS:000290276300002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278543]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Geng, Mei-yu |
| 作者单位 | 1.Ocean Univ China, Sch Med & Pharm, Dept Pharmacol & Glycobiol, Qingdao 266003, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nie, Qin,Du, Xiao-guang,Geng, Mei-yu. Small molecule inhibitors of amyloid beta peptide aggregation as a potential therapeutic strategy for Alzheimer's disease[J]. ACTA PHARMACOLOGICA SINICA,2011,32(5):545-551. |
| APA | Nie, Qin,Du, Xiao-guang,&Geng, Mei-yu.(2011).Small molecule inhibitors of amyloid beta peptide aggregation as a potential therapeutic strategy for Alzheimer's disease.ACTA PHARMACOLOGICA SINICA,32(5),545-551. |
| MLA | Nie, Qin,et al."Small molecule inhibitors of amyloid beta peptide aggregation as a potential therapeutic strategy for Alzheimer's disease".ACTA PHARMACOLOGICA SINICA 32.5(2011):545-551. |
入库方式： OAI收割
来源：上海药物研究所
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