Structure and Synthesis of a Unique Isonitrile Lipid Isolated from the Marine Mollusk Actinocyclus papillatus
文献类型：期刊论文
| 作者 | Manzo, Emiliano2; Carbone, Marianna2; Mollo, Ernesto2; Irace, Carlo3; Di Pascale, Antonio3; Li, Yan1; Ciavatta, Maria Letizia2; Cimino, Guido2; Guo, Yue-Wei1 ; Gavagnin, Margherita2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2011-04-15 |
| 卷号 | 13期号:8页码:1897-1899 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol200377w |
| 文献子类 | Article |
| 英文摘要 | The first chemical study of an Actinocyclidae nudibranch, Actinocyclus papillatus, resulted in the isolation of (-)-actisonitrile (1), a lipid based on a 1,3-propanediol ether skeleton. The structure was established by spectroscopic methods, whereas the absolute configuration of the chiral center was determined by comparing the optical properties of natural actisonitrile with those of (+)- and (-)-synthetic enantiomers, opportunely prepared. Both (-)- and (+)-actisonitrile were tested in preliminary in vitro cytotoxicity bioassays on tumor and nontumor mammalian cells. |
| WOS关键词 | FAMILY DIDEMNIDAE ; TUNICATE ; SERINOL ; SHISHIDIDEMNIOLS |
| 资助项目 | National S & T Major Project[2009ZX09301-001] ; national marine 863 project[2007AA09Z447] ; national marine 863 project[2007AA09Z402] ; NSFC[30730108] ; NSFC[20721003] ; NSFC[20772136] ; CAS[KSX2-YW-R-18] ; STCSM[10540702900] ; MIUR[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000289187200001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278556]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.ICB, CNR, I-80078 Pozzuoli, Na, Italy; 3.Univ Naples Federico 2, Dipartimento Farmacol Sperimentale, Fac Farm, Naples, Italy |
| 推荐引用方式 GB/T 7714 | Manzo, Emiliano,Carbone, Marianna,Mollo, Ernesto,et al. Structure and Synthesis of a Unique Isonitrile Lipid Isolated from the Marine Mollusk Actinocyclus papillatus[J]. ORGANIC LETTERS,2011,13(8):1897-1899. |
| APA | Manzo, Emiliano.,Carbone, Marianna.,Mollo, Ernesto.,Irace, Carlo.,Di Pascale, Antonio.,...&Gavagnin, Margherita.(2011).Structure and Synthesis of a Unique Isonitrile Lipid Isolated from the Marine Mollusk Actinocyclus papillatus.ORGANIC LETTERS,13(8),1897-1899. |
| MLA | Manzo, Emiliano,et al."Structure and Synthesis of a Unique Isonitrile Lipid Isolated from the Marine Mollusk Actinocyclus papillatus".ORGANIC LETTERS 13.8(2011):1897-1899. |
入库方式： OAI收割
来源：上海药物研究所
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