Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in Vitro
文献类型：期刊论文
| 作者 | Chen, Guodong1; Gao, Hao1,3; Tang, Jinshan1; Huang, Yuanfan1; Chen, Ying1; Wang, Ying1; Zhao, Huinan1; Lin, Haipeng2; Xie, Qingyi2; Hong, Kui2 |
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2011-04 |
| 卷号 | 59期号:4页码:447-451 |
| 关键词 | Streptomyces sp. benzamide quinazoline Caspase-3 |
| ISSN号 | 0009-2363 |
| DOI | 10.1248/cpb.59.447 |
| 文献子类 | Article |
| 英文摘要 | One new benzamide,, 3-hydroxyl-2-N-iso-butyryl-anthranilamide (1), together with two known benzamides (2, 3) and three known quinazolines (4-6), was isolated from a mangrove actinomycetes Streptomyces sp. (No. 061316), which displayed inhibiting Caspase-3 activity in vitro. The structure of 1 was elucidated by electrospray ionization (ESI)-MS, NMR spectroscopies and X-ray crystal diffraction. After evaluation of all compounds for their inhibitory effect on,Caspase-3 in vitro, 3-hydroxyl-anthranilamide (2) and 8-hydroxyl-2,4-dioxoquinazoline (6) showed activity against Caspase-3 with IC50 values of 32 and 36 mu M, respectively. |
| WOS关键词 | APOPTOSIS |
| 资助项目 | National Natural Science Foundation of China[U0633008] ; Ministry of Science and Technology of China[2009CB522300] ; Ministry of Science and Technology of China[2008ZX09401-05] ; Ministry of Science and Technology of China[2009ZX09302-004] ; Ministry of Education of China/Fok Ying Tung Education Foundation[121039] ; State Key Laboratory of Drug Rearch[SIMM0812KF-02] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000289748900006 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278560]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Yao, Xinsheng |
| 作者单位 | 1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Jinan Univ Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China; 2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China; 3.Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Guodong,Gao, Hao,Tang, Jinshan,et al. Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in Vitro[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2011,59(4):447-451. |
| APA | Chen, Guodong.,Gao, Hao.,Tang, Jinshan.,Huang, Yuanfan.,Chen, Ying.,...&Yao, Xinsheng.(2011).Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in Vitro.CHEMICAL & PHARMACEUTICAL BULLETIN,59(4),447-451. |
| MLA | Chen, Guodong,et al."Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in Vitro".CHEMICAL & PHARMACEUTICAL BULLETIN 59.4(2011):447-451. |
入库方式： OAI收割
来源：上海药物研究所
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