Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum
文献类型：期刊论文
| 作者 | Lin, Ge1; Wang, Ji Yao2; Li, Na1; Li, Mi1; Gao, Hong2; Ji, Yuan2; Zhang, Fan3; Wang, Huali3; Zhou, Yan4; Ye, Yang5
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| 刊名 | JOURNAL OF HEPATOLOGY
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| 出版日期 | 2011-04 |
| 卷号 | 54期号:4页码:666-673 |
| 关键词 | Hepatic sinusoidal obstruction syndrome Pyrrolizidine alkaloids Pyrrole-protein adducts Tusanqi Erroneous substitution |
| ISSN号 | 0168-8278 |
| DOI | 10.1016/j.jhep.2010.07.031 |
| 文献子类 | Article |
| 英文摘要 | Background & Aims: One major cause of hepatic sinusoidal obstruction syndrome (HSOS) is the intake of pyrrolizidine alkaloid (PA)-containing products. Over 8000 PA-induced HSOS cases have been reported worldwide and at least 51 among them were suspected to be attributed to exposure to the Chinese medicine 'Tusanqi'. PA-induced hepatotoxicity involves cytochrome P450-mediated metabolic activation of PAs to electrophilic pyrrolic metabolites which react with macromolecules, such as proteins. However, no studies have found such protein adduction in HSOS patients. We report one HSOS case confirmed by liver biopsy, where the patient claimed taking 'Tusanqi' as self-medication. Methods: The herb was analyzed by HPLC-MS, and its induced hepatotoxicity in rats was assessed by monitoring the alteration of serum ALT level and liver morphology. Blood pyrrole-protein adducts were determined by UPLC-MS. Results: The herb the patient consumed was identified as Gynura segetum, an erroneous substitute of non-PA-containing Sedum aizoon, called 'Tusanqi'. Hepatotoxic PAs senecionine and seneciphylline were detected in G. segetum. In the PA-exposed patient, serum pyrrole-protein adducts were detected by a newly developed analytical approach. The animal study showed a good correlation of liver injury with the ingestion of G. segetum. Conclusions: For the first time, serum pyrrole-protein adducts were unequivocally detected in a PA-induced HSOS patient, and such adducts show a potential to be developed as a biomarker for the assessment of PA-induced HSOS. Similar to the well-known case of aristolochic acid-poisoning, the observed HSOS was confirmed to arise from the consumption of PA-containing G. segetum, an erroneous substitute of non-PA-containing S. aizoon. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | HEPATOTOXIC PYRROLIZIDINE ALKALOIDS ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; VENOOCCLUSIVE DISEASE ; MICROSOMAL METABOLITES ; CLIVORINE ; LIVER ; RAT ; ACTIVATION ; FOOD |
| 资助项目 | Research Grant Council of Hong Kong[CUHK 2140485] ; Hong Kong Jockey Club Charities Trust[JCICM-15-07] |
| WOS研究方向 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000288831400011 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278573]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Lin, Ge |
| 作者单位 | 1.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China; 2.Fudan Univ, ZhongShan Hosp, Div Gastroenterol, Shanghai 200433, Peoples R China; 3.Univ Washington, Dept Pediat, Ctr Dev Therapeut, Seattle Childrens Res Inst,Div Gastroenterol, Seattle, WA 98195 USA; 4.Hong Kong Jockey Club, Inst Chinese Med, Hong Kong, Hong Kong, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod, Dept Chem, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Ge,Wang, Ji Yao,Li, Na,et al. Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum[J]. JOURNAL OF HEPATOLOGY,2011,54(4):666-673. |
| APA | Lin, Ge.,Wang, Ji Yao.,Li, Na.,Li, Mi.,Gao, Hong.,...&Zheng, Jiang.(2011).Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum.JOURNAL OF HEPATOLOGY,54(4),666-673. |
| MLA | Lin, Ge,et al."Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum".JOURNAL OF HEPATOLOGY 54.4(2011):666-673. |
入库方式： OAI收割
来源：上海药物研究所
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