'Click' to bidentate bis-triazolyl sugar derivatives with promising biological and optical features
文献类型：期刊论文
| 作者 | Song, Zhuo2,3; He, Xiao-Peng2,3,4; Jin, Xiao-Ping2,3; Gao, Li-Xin1; Sheng, Li1; Zhou, Yu-Bo1 ; Li, Jia1; Chen, Guo-Rong2,3
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| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2011-02-23 |
| 卷号 | 52期号:8页码:894-898 |
| 关键词 | Click reaction PTP1B inhibitor Ni(2+) sensor Glycosyl bis-triazole Bidentate O-glucoside |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2010.12.055 |
| 文献子类 | Article |
| 英文摘要 | Bidentate 1-O-methyl-alpha-D-pyranoglucosides bearing two triazolyl alpha-ketoester groups on the 2,6- or 3,4-positions of sugar scaffold were efficiently synthesized via Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (click reaction) in good yields. These newly featured sugar derivatives displayed favorable inhibitory activity on protein tyrosine phosphatase 1B (PTP1B) and unexpected selective fluorescence quenching in the presence of Ni(2+). (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TYROSINE-PHOSPHATASE 1B ; CHEMISTRY ; CYCLOADDITION ; INHIBITOR ; GLYCOSYLATION ; ANALOGS ; CU(II) ; DRUG |
| 资助项目 | National Natural Science Foundation of China[20876045] ; National Natural Science Foundation of China[30801405] ; National Basic Research Program of China[2007CB914201] ; National Science & Technology Major Project of China 'Key New Drug Creation and Manufacturing Program'[2009ZX09302-001] ; Shanghai Science and Technology Community[10410702700] ; Shanghai Science and Technology Community[09DZ2291200] ; Chinese Academy of Sciences[KSCX2-YW-R-168] ; French Embassy in Beijing, PR China[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000287273000013 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278598]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Li, Jia |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 3.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; 4.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Zhuo,He, Xiao-Peng,Jin, Xiao-Ping,et al. 'Click' to bidentate bis-triazolyl sugar derivatives with promising biological and optical features[J]. TETRAHEDRON LETTERS,2011,52(8):894-898. |
| APA | Song, Zhuo.,He, Xiao-Peng.,Jin, Xiao-Ping.,Gao, Li-Xin.,Sheng, Li.,...&Chen, Guo-Rong.(2011).'Click' to bidentate bis-triazolyl sugar derivatives with promising biological and optical features.TETRAHEDRON LETTERS,52(8),894-898. |
| MLA | Song, Zhuo,et al."'Click' to bidentate bis-triazolyl sugar derivatives with promising biological and optical features".TETRAHEDRON LETTERS 52.8(2011):894-898. |
入库方式： OAI收割
来源：上海药物研究所
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