Magnesium lithospermate B decreases [Ca2+](1) in endothelial cells by inhibiting K+ currents
文献类型：期刊论文
| 作者 | Zhang, Haifei; Zhang, Jie; Zha, Ruopeng; Hu, Miaomiao; Wang, Yiping
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2011-01-10 |
| 卷号 | 650期号:1页码:285-289 |
| 关键词 | Endothelial cell Magnesium lithospermate B K+ current Membrane potential |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/j.ejphar.2010.09.028 |
| 文献子类 | Article |
| 英文摘要 | Magnesium lithospermate B (MLB) is a hydrophilic active component of Salviae miltiorrhizae Radix Studies have shown that MLB affected intracellular calcium ([Ca2+](1)) but the underlying mechanism was unclear yet The present work was aimed to investigate the underlying mechanism of MLB affecting [Ca2+](1) in endothelial cells (ECs) Isolated mesentery arteries were employed to test the involvement of L-Ca2+ channel [Ca2+](1) was measured in ECs loaded with Fluo 3 Membrane potential and membrane currents were recorded in ECs using patch-clamp techniques Results showed that MLB did not inhibit Ca2+ influx via L-Ca2+ channel in isolated mesenteric arteries However MLB decreased [Ca2+](1) in a concentration-dependent manner in ECs MLB depolarized the membrane potential of ECs and inhibited K+ currents These results demonstrated that MLB decreased [Ca2+](1) by inhibiting K+ currents and depolarizing membrane potential in ECs (C) 2010 Elsevier B V All rights reserved |
| WOS关键词 | SALVIAE-MILTIORRHIZAE RADIX ; ION CHANNELS ; ACID-B ; CALCIUM ; EXTRACT |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000285893800039 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278626]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Yiping |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Haifei,Zhang, Jie,Zha, Ruopeng,et al. Magnesium lithospermate B decreases [Ca2+](1) in endothelial cells by inhibiting K+ currents[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,650(1):285-289. |
| APA | Zhang, Haifei,Zhang, Jie,Zha, Ruopeng,Hu, Miaomiao,&Wang, Yiping.(2011).Magnesium lithospermate B decreases [Ca2+](1) in endothelial cells by inhibiting K+ currents.EUROPEAN JOURNAL OF PHARMACOLOGY,650(1),285-289. |
| MLA | Zhang, Haifei,et al."Magnesium lithospermate B decreases [Ca2+](1) in endothelial cells by inhibiting K+ currents".EUROPEAN JOURNAL OF PHARMACOLOGY 650.1(2011):285-289. |
入库方式： OAI收割
来源：上海药物研究所
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