Aspergiolides C and D: Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects
文献类型：期刊论文
| 作者 | Du, Lin3; Ai, Jing1 ; Li, Dehai3; Zhu, Tianjiao3; Wang, Ying1; Knauer, Michael2; Bruhn, Torsten2; Liu, Hongbing3; Geng, Meiyu1; Gu, Qianqun3
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| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
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| 出版日期 | 2011 |
| 卷号 | 17期号:4页码:1319-1326 |
| 关键词 | aspergiolides isotopic labeling natural products polyketides quantum chemical calculations receptors |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem201001547 |
| 文献子类 | Article |
| 英文摘要 | Variation of the cultivation conditions for Aspergillus glaucus led to the discovery of two novel spirocyclic aromatic polyketides, aspergiolides C (3) and D (4). Their constitutions were elucidated by a combination of spectroscopic methods and isotope-labeling experiments. Aspergiolides C (3) and D (4) occur as racemic mixtures, the resolution of which was succeeded by HPLC on a chiral phase. The absolute configurations of their enantiomers were assigned online, from the peaks in the chromatogram, by a combination of HPLC-CD and quantum chemical CD calculations. Both compounds were found to inhibit the kinase activities of the receptor tyrosine kinases (RTKs) c-Met, Ron, and c-Src with low-micromolar IC(50)s. The enantiomers of 3 were resolved by HPLC on a chiral phase. Both enantiomers showed a comparable inhibition of the HGF-induced autophosphorylation of c-Met and of subsequent cell migration. |
| WOS关键词 | FUNGUS ASPERGILLUS-GLAUCUS ; GAUSSIAN-BASIS SETS ; METABOLIC PRODUCTS ; TYROSINE KINASES ; ATOMS LI ; GROWTH ; MICROORGANISMS ; DERIVATIVES ; SKELETON ; DENSITY |
| 资助项目 | Chinese National Science Fund[30973627] ; Chinese National Science Fund[30672527] ; National High Technology Research and Development Program of China[2006AA09Z429] ; State Key Laboratory of Drug Research Fund[SIMM0901KF-05] ; Program for Changjiang Scholars and Innovative Research Team in University[IRT0944] ; Deutsche Forschungsgemeinschaft[SFB 630] ; Natural Science Foundation of China for Distinguished Young Scholars[30725046] ; State Key Laboratory of Drug research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000287562300031 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278642]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Geng, Meiyu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Wurzburg Hubland, Inst Organ Chem, D-97074 Wurzburg, Germany; 3.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Lin,Ai, Jing,Li, Dehai,et al. Aspergiolides C and D: Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects[J]. CHEMISTRY-A EUROPEAN JOURNAL,2011,17(4):1319-1326. |
| APA | Du, Lin.,Ai, Jing.,Li, Dehai.,Zhu, Tianjiao.,Wang, Ying.,...&Bringmann, Gerhard.(2011).Aspergiolides C and D: Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects.CHEMISTRY-A EUROPEAN JOURNAL,17(4),1319-1326. |
| MLA | Du, Lin,et al."Aspergiolides C and D: Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects".CHEMISTRY-A EUROPEAN JOURNAL 17.4(2011):1319-1326. |
入库方式： OAI收割
来源：上海药物研究所
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