Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives
文献类型：期刊论文
| 作者 | Luo, Yu1; Xiao, Feng1,2; Qian, Shijing3; Lu, Wei1,4; Yang, Bo3 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2011-01 |
| 卷号 | 46期号:1页码:417-422 |
| 关键词 | Thiazolyl benzimidazole Anticancer Synthesis SMMC-7721 A549 |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2010.11.014 |
| 文献子类 | Article |
| 英文摘要 | A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound lib displayed remarkable in vitro anticancer activity comparable to taxol. The preliminary structure-activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained. (C) 2010 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | BIOLOGICAL-PROPERTIES ; ANTIVIRAL EVALUATION ; ANTICANCER AGENTS ; BENZIMIDAZOLES ; THIAZOLE ; INHIBITORS |
| 资助项目 | Shanghai Municipal Natural Science Foundation[10ZR1409600] ; Lab of Organic Functional Molecules, THE SINO-FRENCH INSTITUTE OF ECNU[00000000] ; Sino-French Institute of ECNU[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000286905400049 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278645]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Lu, Wei |
| 作者单位 | 1.E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China; 2.Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; 4.E China Normal Univ, Inst Drug Discovery & Dev, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Yu,Xiao, Feng,Qian, Shijing,et al. Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2011,46(1):417-422. |
| APA | Luo, Yu,Xiao, Feng,Qian, Shijing,Lu, Wei,&Yang, Bo.(2011).Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,46(1),417-422. |
| MLA | Luo, Yu,et al."Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 46.1(2011):417-422. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。