Selective sp(3) C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component
文献类型：期刊论文
| 作者 | Wang, Jie1; Zhou, Pengfei1; Wang, Yang1,2 |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2011-01 |
| 期号 | 2页码:264-270 |
| 关键词 | C-H activation Friedel-Crafts reaction Lewis acids Carbocations Alkanes Alkylation |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201001118 |
| 文献子类 | Article |
| 英文摘要 | A highly efficient and selective intramolecular Friedel-Crafts reaction of 3-methylbutyl or 4-methylpentyl-substituted aromatics has been developed using a carbocation relay strategy through selective sp(3) C-H bond activation, providing a facile and cost-effective approach for the construction of benzocyclic compounds. A variety of 1,1-dimethylindane and naphthalene derivatives have been prepared from very simple starting materials in good yields with high selectivity. The present strategy has provided a new example of a Friedel-Crafts reaction with alkanes as the alkylating component and constitutes a convenient approach to selective C-H bond activation and functionalization of alkane derivatives. |
| WOS关键词 | REGIOSPECIFIC FUNCTIONALIZATION ; ARYLATION ; COMPLEXES ; PHENOLS ; METHYL |
| 资助项目 | National Natural Science Foundation of China[20972033] ; National Drug Innovative Program[2009ZX09301-011] ; State Key Laboratory of Drug research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000286964500008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278646]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Wang, Yang |
| 作者单位 | 1.Fudan Univ, Dept Med Chem, Sch Pharm, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jie,Zhou, Pengfei,Wang, Yang. Selective sp(3) C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2011(2):264-270. |
| APA | Wang, Jie,Zhou, Pengfei,&Wang, Yang.(2011).Selective sp(3) C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(2),264-270. |
| MLA | Wang, Jie,et al."Selective sp(3) C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .2(2011):264-270. |
入库方式： OAI收割
来源：上海药物研究所
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