Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells
文献类型：期刊论文
| 作者 | Ding, Derong; Zhang, Baozi; Meng, Tao ; Ma, Ying; Wang, Xin; Peng, Hongli; Shen, Jingkang
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 9期号:21页码:7287-7291 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c1ob06094e |
| 文献子类 | Article |
| 英文摘要 | Studies on the anti-proliferative activities of novel baicalein derivatives demonstrated that compounds 8 and 9 were able to activate AMPK by enhancing the levels of phosphorylated AMPK alpha, and showed more potent anti-proliferative effects than baicalein and AICAR in A431, SK-OV-3, DU 145 and HeLa cells, suggesting an alternative therapeutic approach for benzyl baicalein in cancer therapy. |
| WOS关键词 | SCUTELLARIA-BAICALENSIS ; IN-VITRO ; METABOLIC-DISORDERS ; CANCER CELLS ; INHIBITION ; CARCINOMA ; FLAVONES ; GROWTH ; ENERGY ; LINES |
| 资助项目 | National Natural Science Foundation of China[81172921] ; 863 Program (the National High Technology Research and Development Program of China)[2007AA02Z308] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000295890100003 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278673]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Peng, Hongli |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Derong,Zhang, Baozi,Meng, Tao,et al. Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2011,9(21):7287-7291. |
| APA | Ding, Derong.,Zhang, Baozi.,Meng, Tao.,Ma, Ying.,Wang, Xin.,...&Shen, Jingkang.(2011).Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells.ORGANIC & BIOMOLECULAR CHEMISTRY,9(21),7287-7291. |
| MLA | Ding, Derong,et al."Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells".ORGANIC & BIOMOLECULAR CHEMISTRY 9.21(2011):7287-7291. |
入库方式： OAI收割
来源：上海药物研究所
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