Synthesis and antitumor evaluation of methyl spongoate analogs
文献类型：期刊论文
| 作者 | Jiang, Cheng-Shi1; Huang, Cai-Guo2; Feng, Bo2; Li, Jia1 ; Gong, Jing-Xu1; Kurtan, Tibor3; Guo, Yue-Wei1
|
| 刊名 | STEROIDS
 |
| 出版日期 | 2010-12-12 |
| 卷号 | 75期号:13-14页码:1153-1163 |
| 关键词 | Synthesis Methyl spongoate analogs Cytotoxicity Michael acceptor |
| ISSN号 | 0039-128X |
| DOI | 10.1016/j.steroids.2010.08.002 |
| 文献子类 | Article |
| 英文摘要 | A series of novel methyl spongoate (1) analogs has been synthesized and evaluated for their in vitro cytotoxic properties. It was found that the nature of the C-20 side chain had significant effects on their bioactivities and some analogs showed higher cytotoxicity than 1 against A549, HCT-116, HepG2, SW-1990, MCF-7 and NCl-H460 tumor cell lines. The pharmacological results confirmed that the alpha,beta-unsaturated carbonyl moiety, a Michael acceptor in ring A, plays a pivotal role in the cytotoxic effect of these derivatives. The compiled pharmacological data may be useful for the design of novel analogous anticancer drugs. (C) 2010 Elsevier Inc. All rights reserved. |
| WOS关键词 | ALPHA,BETA-UNSATURATED CARBONYL SYSTEMS ; CYTOTOXIC AGENTS ; SOFT CORAL ; ACID ; STEROIDS ; KETONES ; DERIVATIVES ; APOPTOSIS ; BINDING ; CANCER |
| 资助项目 | National ST Major Project[2009ZX09301-001] ; National ST Major Project[2009ZX09103-060] ; National Science Foundation of China[30730108] ; National Science Foundation of China[20721003] ; STCSM[09ZR1438000] ; STCSM[10540702900] ; CAS[SIMM0907KF-09] ; TRF-NSFC[20911140471] ; Hungarian-Chinese Intergovernment S&T Cooperation Programme[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000283613700015 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278690]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Gong, Jing-Xu |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Second Mil Med Univ, Shanghai 200433, Peoples R China; 3.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary |
| 推荐引用方式 GB/T 7714 | Jiang, Cheng-Shi,Huang, Cai-Guo,Feng, Bo,et al. Synthesis and antitumor evaluation of methyl spongoate analogs[J]. STEROIDS,2010,75(13-14):1153-1163. |
| APA | Jiang, Cheng-Shi.,Huang, Cai-Guo.,Feng, Bo.,Li, Jia.,Gong, Jing-Xu.,...&Guo, Yue-Wei.(2010).Synthesis and antitumor evaluation of methyl spongoate analogs.STEROIDS,75(13-14),1153-1163. |
| MLA | Jiang, Cheng-Shi,et al."Synthesis and antitumor evaluation of methyl spongoate analogs".STEROIDS 75.13-14(2010):1153-1163. |
入库方式： OAI收割
来源：上海药物研究所
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