High Throughput Screening for Bioactive Components from Traditional Chinese Medicine
文献类型：期刊论文
| 作者 | Zhu, Yanhui1; Zhang, Zhiyun1; Zhang, Meng1; Mais, Dale E.2; Wang, Ming-Wei1
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| 刊名 | COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
 |
| 出版日期 | 2010-12 |
| 卷号 | 13期号:10页码:837-848 |
| 关键词 | Traditional Chinese medicine natural products high throughput screening drug discovery |
| ISSN号 | 1386-2073 |
| DOI | 10.2174/138620710793360257 |
| 文献子类 | Article |
| 英文摘要 | Throughout the centuries, traditional Chinese medicine has been a rich resource in the development of new drugs. Modern drug discovery, which relies increasingly on automated high throughput screening and quick hit-to-lead development, however, is confronted with the challenges of the chemical complexity associated with natural products. New technologies for biological screening as well as library building are in great demand in order to meet the requirements. Here we review the developments in these techniques under the perspective of their applicability in natural product drug discovery. Methods in library construction, component characterization, biological evaluation, and other screening approaches including NMR and X-ray diffraction are discussed. |
| WOS关键词 | NATURAL-PRODUCT EXTRACTS ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; TIME-RESOLVED FLUORESCENCE ; LONGDAN-XIEGAN-DECOCTION ; ANIMAL INFECTION MODEL ; HIGH-AFFINITY LIGANDS ; REPORTER GENE ASSAYS ; MASS-SPECTROMETRY ; DRUG DISCOVERY ; PROTEIN-BINDING |
| 资助项目 | Ministry of Science and Technology of China[2009ZX09302-001] ; Shanghai Municipality Government[08DZ2291300] ; Shanghai Municipality government[09DZ2291200] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000284622300003 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278703]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Ming-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.MPI Res, Mattawan, MI 49071 USA |
| 推荐引用方式 GB/T 7714 | Zhu, Yanhui,Zhang, Zhiyun,Zhang, Meng,et al. High Throughput Screening for Bioactive Components from Traditional Chinese Medicine[J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2010,13(10):837-848. |
| APA | Zhu, Yanhui,Zhang, Zhiyun,Zhang, Meng,Mais, Dale E.,&Wang, Ming-Wei.(2010).High Throughput Screening for Bioactive Components from Traditional Chinese Medicine.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,13(10),837-848. |
| MLA | Zhu, Yanhui,et al."High Throughput Screening for Bioactive Components from Traditional Chinese Medicine".COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 13.10(2010):837-848. |
入库方式： OAI收割
来源：上海药物研究所
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