Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities
文献类型：期刊论文
| 作者 | Chen, Yu1,2,3; Fan, Hua4; Yang, Guang-zhong1,2,4; Jiang, Yan4; Zhong, Fang-fang4; He, Hong-wu1,2 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2010-10 |
| 卷号 | 15期号:10页码:7438-7449 |
| 关键词 | Xanthones Garcinia xanthochymus DPPH radical scavenging activity |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules15107438 |
| 文献子类 | Article |
| 英文摘要 | Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC50 value of 19.64 mu M, and compound 6 showed the lowest activity among all the tested molecules, with an IC50 value of 66.88 mu M. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds. |
| WOS关键词 | ROOT BARK ; ANTIOXIDANT ; FRUITS ; BENZOPHENONES |
| 资助项目 | State Key Laboratory of Drug Research[SIMM0901KF-02] ; National Basic Research Program of China[2010CB126100] ; National Natural Science Foundation of China[30670215] ; National Natural Science Foundation of China[20772042] ; PCSIRT[IRT0953] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000283587400051 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278765]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Guang-zhong |
| 作者单位 | 1.Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.S Cent Univ Nationalities, Coll Chem & Mat Sci, Wuhan 430074, Peoples R China; 4.S Cent Univ Nationalities, Coll Pharm, Lab Nat Prod Chem, Wuhan 430074, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yu,Fan, Hua,Yang, Guang-zhong,et al. Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities[J]. MOLECULES,2010,15(10):7438-7449. |
| APA | Chen, Yu,Fan, Hua,Yang, Guang-zhong,Jiang, Yan,Zhong, Fang-fang,&He, Hong-wu.(2010).Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities.MOLECULES,15(10),7438-7449. |
| MLA | Chen, Yu,et al."Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities".MOLECULES 15.10(2010):7438-7449. |
入库方式： OAI收割
来源：上海药物研究所
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