Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems
文献类型：期刊论文
| 作者 | Chu, Hong-yuan; Zhen, Xuechu |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2010-09 |
| 卷号 | 31期号:9页码:1036-1043 |
| 关键词 | dopamine drug addiction hyperpolarization-activated nucleotide-gated channels (HCN channels) midbrain Parkinson's disease |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2010.105 |
| 文献子类 | Review |
| 英文摘要 | Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN channels) are expressed widely in the brain and invovled in various neuronal activities, including the control of neuronal rhythmic activity, setting the resting membrane potential, as well as dendritic integration. HCN channels also participate in the regulation of spontaneous activity of midbrain dopamine (DA) neurons to some extent. In slice preparations of midbrain, a hyperpolarization-activated non-selective cation current (Ih) mediated by the channels has been proposed as an electrophysiological marker to identify DA neurons. Recent evidence, however, shows that the functional roles of HCN channels in midbrain DA neurons are obviously underestimated. Here, we review the recent advances in the studies of the functional roles of Ih in midbrain DA neurons and further, their involvement in drug addiction and Parkinson's disease. |
| WOS关键词 | VENTRAL TEGMENTAL AREA ; CURRENT I-H ; NIGRA ZONA COMPACTA ; PROTEIN-KINASE-C ; HIPPOCAMPAL PYRAMIDAL NEURONS ; CATION CURRENT ; PARKINSONS-DISEASE ; PACEMAKER CHANNELS ; WORKING-MEMORY ; PARS-COMPACTA |
| 资助项目 | National Natural Science Foundation of China[30770662] ; National Natural Science Foundation of China[30825042] ; National Natural Science Foundation of China[20872153] ; Ministry of Science and Technology of China[2007AA02z163] ; Ministry of Science and Technology of China[2009CB522201] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3989603 |
| WOS记录号 | WOS:000281562900007 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278780]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhen, Xuechu |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Dept Neuropharmacol 2, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chu, Hong-yuan,Zhen, Xuechu. Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems[J]. ACTA PHARMACOLOGICA SINICA,2010,31(9):1036-1043. |
| APA | Chu, Hong-yuan,&Zhen, Xuechu.(2010).Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems.ACTA PHARMACOLOGICA SINICA,31(9),1036-1043. |
| MLA | Chu, Hong-yuan,et al."Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems".ACTA PHARMACOLOGICA SINICA 31.9(2010):1036-1043. |
入库方式： OAI收割
来源：上海药物研究所
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